Setting description

Hormone_therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 35 4 2 2
TP53- & AR- 405 1 1 3
TP53+ 3 9 3 4
DRD+ 7 0 1 2
TEfus+ 10 3 2 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.070 0.008 0.004 0.004
TP53- & AR- 0.810 0.002 0.002 0.006
TP53+ 0.006 0.018 0.006 0.008
DRD+ 0.014 0.000 0.002 0.004
TEfus+ 0.020 0.006 0.004 0.006
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 3 2 3
TP53- & AR- 2 396 391 382
TP53+ 29 29 35 30
DRD+ 2 40 41 42
TEfus+ 3 48 42 30
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.006 0.004 0.006
TP53- & AR- 0.004 0.792 0.782 0.764
TP53+ 0.058 0.058 0.070 0.060
DRD+ 0.004 0.080 0.082 0.084
TEfus+ 0.006 0.096 0.084 0.060
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 49 11 16 27
TP53+ 10 12 8 9
DRD+ 0 0 0 0
TEfus+ 0 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.098 0.022 0.032 0.054
TP53+ 0.020 0.024 0.016 0.018
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.132.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.062             0.034             0.016             0.028 

The overall power was 0.81.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.81              0.00              0.00              0.00 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 35 4 2 2
futility 0 1 3 2 3
max_n 0 0 0 0 0
n 418 (351, 460) 158 (95, 262) 168 (120, 246) 166 (119, 235) 167 (122, 252)
n_unique 386 (324, 426) 145 (88, 246) 155 (111, 230) 152 (109, 219) 155 (111, 237)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (3, 6) 6 (4, 6) 7 (6, 11) 22 (6, 28)
post_p NA (NA, NA) 0.97 (0.64, 1) 0.04 (0, 0.29) 0.05 (0, 0.29) 0.05 (0, 0.34)
rate 0.094 (0.087, 0.102) 0.078 (0.06, 0.09) 0.113 (0.102, 0.128) 0.113 (0.102, 0.126) 0.112 (0.101, 0.126)
TP53- & AR- graduation 0 405 1 1 3
futility 0 2 396 391 382
max_n 0 49 11 16 27
n 177 (109, 206) 34 (25, 150) 41 (25, 120) 44 (26, 122) 46 (25, 134)
n_unique 165 (98, 193) 32 (24, 141) 36 (23, 111) 40 (23, 114) 42 (23, 127)
time_trial 36 (36, 36) 10 (7, 36) 25 (14, 36) 23 (14, 36) 24 (14, 36)
time_stop NA (NA, NA) 9 (6, 20) 21 (13, 33) 20 (13, 31) 21 (13, 32)
post_p NA (NA, NA) 1 (0.97, 1) 0.01 (0, 0.12) 0.01 (0, 0.15) 0.02 (0, 0.12)
rate 0.075 (0.064, 0.084) 0.041 (0.031, 0.051) 0.116 (0.098, 0.152) 0.115 (0.095, 0.143) 0.114 (0.097, 0.145)
TP53+ graduation 0 3 9 3 4
futility 0 29 29 35 30
max_n 0 10 12 8 9
n 184 (162, 210) 84 (33, 122) 89 (53, 127) 82 (54, 119) 86 (51, 126)
n_unique 170 (148, 194) 76 (31, 114) 81 (49, 118) 76 (49, 111) 79 (47, 117)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 19 (11, 29) 15 (8, 31) 20 (13, 35) 19 (11, 32)
post_p NA (NA, NA) 0.52 (0.09, 0.89) 0.53 (0.11, 0.9) 0.49 (0.1, 0.9) 0.51 (0.1, 0.88)
rate 0.113 (0.101, 0.124) 0.112 (0.096, 0.137) 0.112 (0.097, 0.135) 0.113 (0.097, 0.138) 0.113 (0.097, 0.135)
DRD+ graduation 0 7 0 1 2
futility 0 2 40 41 42
max_n 0 0 0 0 0
n 112 (92, 128) 37 (18, 58) 47 (26, 70) 58 (39, 81) 58 (37, 80)
n_unique 102 (84, 118) 33 (17, 53) 43 (24, 65) 53 (35, 74) 53 (33, 73)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 26 (20, 29) 26 (20, 34) 24 (15, 34) 24 (14, 34)
post_p NA (NA, NA) 0.62 (0.18, 0.95) 0.26 (0.04, 0.71) 0.2 (0.02, 0.67) 0.19 (0.02, 0.68)
rate 0.097 (0.083, 0.113) 0.091 (0.068, 0.125) 0.112 (0.093, 0.146) 0.114 (0.094, 0.141) 0.115 (0.096, 0.143)
TEfus+ graduation 0 10 3 2 3
futility 0 3 48 42 30
max_n 0 0 0 0 0
n 151 (127, 173) 59 (28, 88) 71 (42, 100) 68 (42, 97) 69 (45, 98)
n_unique 138 (117, 158) 55 (26, 80) 66 (39, 92) 62 (39, 89) 64 (40, 90)
time_trial 36 (36, 36) 36 (36, 36) 36 (35, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 16 (12, 28) 20 (11, 32) 20 (15, 35) 21 (14, 34)
post_p NA (NA, NA) 0.72 (0.24, 0.97) 0.24 (0.04, 0.7) 0.27 (0.04, 0.73) 0.27 (0.03, 0.68)
rate 0.1 (0.088, 0.113) 0.092 (0.072, 0.115) 0.114 (0.097, 0.139) 0.113 (0.096, 0.135) 0.112 (0.096, 0.139)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 439 404 396 387
futility 0 0 0 0 0
max_n 0 49 11 16 27
n 114 (70, 136) 27 (19, 107) 21 (8, 76) 19 (8, 74) 22 (8, 83)
n_unique 106 (62, 128) 25 (17, 103) 19 (7, 72) 18 (7, 71) 20 (7, 79)
post_p NA (NA, NA) 1 (0.93, 1) 0.06 (0.01, 0.3) 0.08 (0.01, 0.31) 0.07 (0, 0.32)
rate 0.074 (0.064, 0.087) 0.041 (0.03, 0.053) 0.119 (0.093, 0.183) 0.117 (0.09, 0.173) 0.116 (0.09, 0.18)
—+ graduation 0 439 409 403 389
futility 0 0 0 0 0
max_n 0 49 11 16 27
n 20 (12, 28) 4 (2, 14) 7 (3, 17) 6 (2, 17) 6 (2, 19)
n_unique 18 (10, 26) 4 (1, 13) 6 (2, 16) 5 (1, 16) 6 (2, 17)
post_p NA (NA, NA) 0.83 (0.45, 0.98) 0.24 (0.08, 0.52) 0.3 (0.12, 0.61) 0.27 (0.09, 0.57)
rate 0.076 (0.051, 0.11) 0.044 (0.018, 0.096) 0.136 (0.083, 0.299) 0.127 (0.075, 0.328) 0.127 (0.077, 0.342)
–+- graduation 0 68 45 41 36
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 62 (49, 77) 26 (8, 56) 26 (8, 57) 22 (7, 52) 24 (6, 54)
n_unique 57 (45, 72) 24 (7, 52) 23 (7, 54) 20 (6, 50) 22 (5, 50)
post_p NA (NA, NA) 0.46 (0.1, 0.87) 0.45 (0.12, 0.88) 0.43 (0.11, 0.85) 0.42 (0.11, 0.86)
rate 0.112 (0.094, 0.136) 0.118 (0.09, 0.191) 0.117 (0.088, 0.202) 0.12 (0.092, 0.206) 0.118 (0.091, 0.211)
–++ graduation 0 79 88 76 66
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 41 (32, 53) 17 (4, 36) 18 (7, 41) 14 (4, 34) 14 (5, 35)
n_unique 38 (29, 50) 15 (3, 34) 17 (6, 39) 12 (3, 31) 14 (4, 33)
post_p NA (NA, NA) 0.49 (0.15, 0.87) 0.48 (0.13, 0.87) 0.45 (0.15, 0.85) 0.44 (0.14, 0.83)
rate 0.113 (0.09, 0.143) 0.119 (0.082, 0.227) 0.117 (0.089, 0.195) 0.119 (0.085, 0.276) 0.121 (0.086, 0.228)
-+– graduation 0 439 407 401 394
futility 0 0 0 0 0
max_n 0 49 11 16 26
n 19 (11, 27) 2 (0, 11) 7 (2, 17) 8 (3, 20) 8 (3, 19)
n_unique 18 (10, 25) 1 (0, 11) 6 (1, 16) 7 (3, 18) 7 (2, 18)
post_p NA (NA, NA) 0.78 (0.42, 0.96) 0.3 (0.11, 0.62) 0.25 (0.09, 0.58) 0.27 (0.09, 0.58)
rate 0.076 (0.052, 0.11) 0.043 (0, 0.129) 0.126 (0.078, 0.363) 0.126 (0.079, 0.281) 0.127 (0.08, 0.301)
-+-+ graduation 0 439 412 407 395
futility 0 0 0 0 0
max_n 0 49 11 16 26
n 20 (12, 28) 2 (0, 11) 6 (2, 18) 8 (3, 19) 8 (3, 20)
n_unique 18 (11, 26) 2 (0, 11) 5 (2, 17) 7 (3, 17) 7 (3, 18)
post_p NA (NA, NA) 0.75 (0.4, 0.96) 0.3 (0.11, 0.6) 0.26 (0.1, 0.58) 0.25 (0.08, 0.56)
rate 0.074 (0.052, 0.109) 0.049 (0.015, 0.135) 0.125 (0.078, 0.308) 0.122 (0.081, 0.259) 0.129 (0.085, 0.302)
-++- graduation 0 77 76 74 71
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 12 (7, 17) 4 (1, 11) 4 (1, 11) 6 (2, 13) 6 (2, 12)
n_unique 11 (7, 16) 4 (1, 10) 4 (1, 10) 5 (2, 12) 6 (2, 11)
post_p NA (NA, NA) 0.47 (0.22, 0.82) 0.45 (0.23, 0.81) 0.46 (0.2, 0.8) 0.44 (0.21, 0.82)
rate 0.117 (0.073, 0.179) 0.13 (0.063, 0.45) 0.132 (0.066, 0.418) 0.135 (0.074, 0.391) 0.131 (0.071, 0.323)
-+++ graduation 0 88 113 102 97
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 12 (7, 18) 4 (1, 10) 4 (1, 10) 6 (2, 13) 6 (2, 13)
n_unique 11 (6, 16) 4 (1, 9) 4 (1, 9) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.47 (0.23, 0.82) 0.46 (0.22, 0.82) 0.44 (0.23, 0.82) 0.44 (0.2, 0.84)
rate 0.118 (0.078, 0.175) 0.129 (0.065, 0.383) 0.132 (0.068, 0.431) 0.139 (0.07, 0.322) 0.137 (0.072, 0.396)
+— graduation 0 36 7 4 5
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 20 (14, 27) 8 (2, 18) 10 (4, 20) 8 (3, 17) 8 (2, 18)
n_unique 18 (12, 25) 7 (2, 17) 9 (3, 19) 7 (3, 16) 7 (2, 16)
post_p NA (NA, NA) 0.48 (0.2, 0.84) 0.45 (0.15, 0.83) 0.48 (0.19, 0.85) 0.44 (0.19, 0.85)
rate 0.113 (0.085, 0.169) 0.125 (0.074, 0.265) 0.124 (0.08, 0.305) 0.12 (0.075, 0.283) 0.125 (0.075, 0.308)
+–+ graduation 0 49 58 48 36
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 16 (10, 22) 6 (2, 15) 8 (3, 17) 6 (2, 15) 6 (2, 15)
n_unique 15 (10, 21) 6 (1, 14) 7 (2, 15) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.45 (0.2, 0.82) 0.43 (0.17, 0.85) 0.47 (0.21, 0.83) 0.46 (0.21, 0.83)
rate 0.114 (0.083, 0.162) 0.128 (0.075, 0.334) 0.13 (0.079, 0.321) 0.124 (0.07, 0.343) 0.127 (0.071, 0.392)
+-+- graduation 0 68 45 41 36
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 16 (11, 23) 6 (2, 14) 8 (3, 16) 6 (2, 14) 7 (2, 15)
n_unique 15 (9, 21) 5 (1, 13) 7 (3, 16) 5 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.43 (0.2, 0.81) 0.45 (0.19, 0.82) 0.48 (0.21, 0.84) 0.48 (0.22, 0.84)
rate 0.116 (0.081, 0.17) 0.133 (0.073, 0.34) 0.127 (0.081, 0.281) 0.122 (0.071, 0.332) 0.125 (0.07, 0.293)
+-++ graduation 0 79 88 76 66
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 16 (10, 22) 6 (1, 15) 7 (2, 17) 6 (2, 15) 6 (2, 14)
n_unique 14 (10, 20) 5 (1, 13) 7 (2, 16) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.44 (0.2, 0.8) 0.45 (0.19, 0.81) 0.49 (0.21, 0.83) 0.48 (0.2, 0.82)
rate 0.113 (0.081, 0.166) 0.127 (0.074, 0.392) 0.128 (0.081, 0.312) 0.122 (0.073, 0.362) 0.122 (0.068, 0.358)
++– graduation 0 45 47 45 47
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 16) 4 (1, 10) 4 (1, 10) 6 (2, 13) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 4 (1, 10) 6 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.46 (0.23, 0.8) 0.46 (0.22, 0.78) 0.49 (0.21, 0.83) 0.45 (0.19, 0.83)
rate 0.116 (0.074, 0.181) 0.13 (0.067, 0.381) 0.129 (0.068, 0.39) 0.123 (0.069, 0.339) 0.133 (0.073, 0.383)
++-+ graduation 0 58 91 77 73
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 17) 4 (1, 10) 4 (1, 11) 6 (2, 13) 6 (2, 13)
n_unique 10 (6, 16) 3 (1, 9) 4 (1, 10) 5 (2, 12) 6 (2, 13)
post_p NA (NA, NA) 0.46 (0.22, 0.8) 0.46 (0.23, 0.82) 0.47 (0.2, 0.82) 0.47 (0.21, 0.85)
rate 0.116 (0.075, 0.177) 0.132 (0.07, 0.493) 0.132 (0.07, 0.428) 0.128 (0.074, 0.373) 0.125 (0.07, 0.392)
+++- graduation 0 77 76 74 71
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 11 (7, 17) 4 (1, 10) 4 (1, 11) 6 (2, 12) 6 (2, 13)
n_unique 10 (6, 16) 4 (1, 9) 4 (1, 10) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.48 (0.21, 0.82) 0.46 (0.24, 0.83) 0.45 (0.2, 0.83) 0.44 (0.2, 0.81)
rate 0.111 (0.074, 0.176) 0.124 (0.065, 0.421) 0.127 (0.063, 0.503) 0.126 (0.07, 0.333) 0.131 (0.074, 0.388)
++++ graduation 0 88 113 102 97
futility 0 0 0 0 0
max_n 0 10 12 8 9
n 12 (7, 17) 4 (1, 11) 4 (1, 11) 6 (2, 13) 6 (2, 12)
n_unique 11 (7, 16) 4 (1, 10) 4 (1, 10) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.44 (0.23, 0.81) 0.47 (0.23, 0.81) 0.43 (0.19, 0.85) 0.46 (0.2, 0.81)
rate 0.115 (0.073, 0.175) 0.131 (0.065, 0.438) 0.127 (0.062, 0.422) 0.132 (0.07, 0.359) 0.125 (0.071, 0.382)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 35 4 2 2
time_stop 4 (3, 7) 6 (5, 7) 6 (6, 7) 6 (5, 8)
n_trt 29 (26, 49) 38 (28, 43) 28 (26, 30) 31 (28, 34)
n_control 49 (40, 71) 70 (52, 78) 76 (68, 84) 67 (56, 78)
post_p 0.94 (0.88, 0.98) 0.92 (0.9, 0.95) 0.98 (0.98, 0.98) 0.91 (0.88, 0.95)
order 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 1)
TP53- & AR- count 405 1 1 3
time_stop 9 (6, 21) 11 (11, 11) 8 (8, 8) 13 (10, 15)
n_trt 33 (26, 79) 27 (27, 27) 25 (25, 25) 26 (25, 48)
n_control 41 (28, 104) 37 (37, 37) 37 (37, 37) 58 (39, 79)
post_p 0.95 (0.87, 1) 0.96 (0.96, 0.96) 0.85 (0.85, 0.85) 0.9 (0.88, 0.95)
order 1 (1, 1) 1 (1, 1) 2 (2, 2) 2 (1.2, 2)
TP53+ count 3 9 3 4
time_stop 12 (10, 14) 9 (7, 13) 11 (9, 13) 16 (10, 20)
n_trt 42 (30, 46) 29 (26, 40) 33 (28, 40) 40 (29, 52)
n_control 44 (35, 70) 42 (31, 71) 57 (43, 59) 70 (47, 90)
post_p 0.94 (0.94, 0.97) 0.96 (0.91, 0.98) 0.97 (0.89, 0.99) 0.98 (0.94, 1)
order 2 (1.2, 2) 1 (1, 2.2) 2 (1.2, 2) 1.5 (1, 2)
DRD+ count 7 1 2
time_stop 26 (20, 30) 10 (10, 10) 12 (9, 14)
n_trt 26 (25, 34) 25 (25, 25) 31 (27, 35)
n_control 80 (55, 86) 29 (29, 29) 36 (30, 42)
post_p 0.95 (0.93, 0.99) 0.92 (0.92, 0.92) 0.9 (0.88, 0.91)
order 2 (2, 2.4) 2 (2, 2) 1 (1, 1)
TEfus+ count 10 3 2 3
time_stop 15 (12, 23) 11 (8, 13) 12 (10, 14) 12 (11, 13)
n_trt 28 (25, 36) 25 (25, 35) 28 (27, 29) 29 (28, 29)
n_control 56 (43, 85) 46 (30, 54) 58 (47, 70) 45 (39, 50)
post_p 0.98 (0.93, 1) 0.94 (0.89, 0.94) 0.96 (0.96, 0.96) 0.92 (0.9, 0.92)
order 2 (2, 2.1) 2 (1.2, 2) 2.5 (2.1, 2.9) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1 3 2 3
time_stop 3 (3, 3) 5 (3, 6) 10 (8, 12) 28 (23, 28)
n_trt 26 (26, 26) 28 (26, 38) 44 (29, 58) 107 (85, 167)
n_control 31 (31, 31) 56 (38, 63) 105 (84, 126) 332 (268, 347)
post_p 0.15 (0.15, 0.15) 0.08 (0.06, 0.17) 0.02 (0.01, 0.04) 0 (0, 0.01)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 4 (2.4, 6.4)
TP53- & AR- count 2 396 391 382
time_stop 6 (6, 7) 21 (13, 33) 20 (13, 31) 21 (13, 32)
n_trt 28 (26, 29) 36 (25, 94) 38 (26, 87) 35 (25, 96)
n_control 33 (32, 34) 107 (57, 178) 101 (59, 165) 104 (58, 174)
post_p 0.15 (0.13, 0.18) 0.05 (0, 0.2) 0.06 (0, 0.2) 0.05 (0, 0.18)
order 1 (1, 1) 2 (1, 4) 2 (1, 3) 2 (1, 4)
TP53+ count 29 29 35 30
time_stop 20 (11, 29) 22 (9, 33) 20 (13, 35) 19 (12, 33)
n_trt 34 (27, 62) 37 (26, 76) 38 (26, 61) 36 (26, 67)
n_control 95 (40, 148) 107 (44, 164) 101 (60, 181) 94 (53, 170)
post_p 0.04 (0, 0.19) 0.06 (0, 0.16) 0.05 (0.01, 0.14) 0.05 (0.01, 0.15)
order 2 (1, 4) 2 (1, 5) 2 (1, 5) 3 (1, 5)
DRD+ count 2 40 41 42
time_stop 26 (24, 27) 26 (20, 34) 24 (16, 34) 26 (14, 34)
n_trt 26 (25, 27) 29 (25, 44) 39 (27, 54) 36 (26, 52)
n_control 82 (78, 86) 78 (55, 114) 70 (45, 105) 78 (42, 106)
post_p 0.04 (0.02, 0.07) 0.04 (0, 0.17) 0.04 (0.01, 0.14) 0.04 (0.01, 0.1)
order 3.5 (2.3, 4.7) 4 (1, 5) 3 (2, 5) 3 (1, 5)
TEfus+ count 3 48 42 30
time_stop 26 (19, 28) 20 (12, 32) 20 (15, 35) 22 (16, 34)
n_trt 29 (27, 36) 38 (26, 63) 36 (26, 58) 42 (28, 60)
n_control 121 (72, 126) 81 (41, 138) 90 (56, 148) 88 (54, 140)
post_p 0.12 (0.05, 0.14) 0.04 (0.01, 0.15) 0.05 (0.01, 0.12) 0.05 (0.01, 0.19)
order 3 (1.4, 3.8) 2.5 (1, 4.3) 3 (1, 5) 3 (1, 6.1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35
time 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7)
n 15 (12, 22) 2 (1, 6) 6 (3, 10) 2 (0, 7) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 2) 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
post_p 0.76 (0.64, 0.9) 0.63 (0.54, 0.71) 0.65 (0.54, 0.77) 0.59 (0.52, 0.73) 0.54 (0.51, 0.58) 0.54 (0.53, 0.57) 0.54 (0.51, 0.56) 0.51 (0.51, 0.61) 0.6 (0.53, 0.69) 0.57 (0.51, 0.69) 0.58 (0.51, 0.64) 0.59 (0.52, 0.67) NA (NA, NA) 0.52 (0.51, 0.52) 0.52 (0.51, 0.55) 0.52 (0.51, 0.54)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.048) 0 (0, 0.025) 0.05 (0, 0.134) 0 (0, 0.083) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.094) 0 (0, 0.108) 0 (0, 0.54) 0 (0, 0) 0 (0, 0) 0 (0, 0.205) 0 (0, 0)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
n 4 (2, 8) 2 (0, 4) 6 (3, 9) 6 (4, 7) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 1) 6 (4, 6) 3 (2, 3) 3 (2, 4) 4 (2, 5) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1)
post_p 0.56 (0.54, 0.65) 0.59 (0.52, 0.66) 0.74 (0.66, 0.89) 0.66 (0.56, 0.72) 0.54 (0.52, 0.55) 0.57 (0.55, 0.58) 0.59 (0.59, 0.59) 0.51 (0.51, 0.51) 0.63 (0.54, 0.66) 0.64 (0.53, 0.75) 0.73 (0.61, 0.81) 0.59 (0.52, 0.73) 0.56 (0.56, 0.56) 0.51 (0.51, 0.51) NA (NA, NA) 0.52 (0.52, 0.52)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.088) 0 (0, 0) 0 (0, 0.03) 0.019 (0, 0.067) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.096 (0.056, 0.172) 0.108 (0.032, 0.138) 0 (0, 0.033) 0.041 (0, 0.113) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
n 4 (3, 4) 1 (1, 1) 3 (1, 5) 0 (0, 0) 4 (4, 4) 0 (0, 1) 2 (2, 3) 2 (2, 2) 0 (0, 1) 2 (1, 4) 2 (2, 3) 1 (1, 1) 2 (2, 2) 1 (0, 2) 1 (0, 2) 2 (1, 2)
post_p 0.59 (0.57, 0.6) 0.56 (0.56, 0.56) 0.59 (0.54, 0.64) NA (NA, NA) 0.72 (0.71, 0.73) 0.57 (0.57, 0.57) 0.52 (0.52, 0.52) 0.56 (0.53, 0.58) 0.5 (0.5, 0.5) 0.53 (0.52, 0.53) 0.63 (0.58, 0.68) 0.51 (0.5, 0.52) 0.77 (0.76, 0.78) 0.51 (0.51, 0.51) 0.76 (0.76, 0.76) 0.63 (0.58, 0.68)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.037 (0.007, 0.066) NA (NA, NA) 0.031 (0.006, 0.056) 0 (0, 0) 0.043 (0.009, 0.078) 0.152 (0.03, 0.273) 0 (0, 0) 0.074 (0.015, 0.133) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8)
n 2 (1, 3) 0 (0, 1) 6 (4, 8) 1 (1, 1) 2 (1, 3) 2 (2, 3) 3 (3, 3) 2 (2, 2) 2 (1, 3) 0 (0, 0) 0 (0, 1) 0 (0, 1) 2 (1, 3) 3 (2, 4) 2 (1, 2) 2 (2, 3)
post_p 0.58 (0.55, 0.6) 0.56 (0.56, 0.56) 0.51 (0.51, 0.52) 0.54 (0.52, 0.56) 0.62 (0.57, 0.67) 0.63 (0.59, 0.66) 0.73 (0.71, 0.75) 0.6 (0.56, 0.64) 0.56 (0.54, 0.59) NA (NA, NA) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) 0.63 (0.59, 0.66) 0.62 (0.62, 0.62) 0.57 (0.54, 0.59) 0.65 (0.6, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.096 (0.083, 0.108) 0 (0, 0) 0 (0, 0) 0.057 (0.011, 0.102) 0.061 (0.012, 0.111) 0.065 (0.013, 0.117) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.096 (0.019, 0.173) 0.078 (0.016, 0.14) 0.024 (0.005, 0.043)
TP53- & AR- Hormone_therapies count 405 405 405 405
time 9 (6, 21) 9 (6, 21) 9 (6, 21) 9 (6, 21)
n 26 (20, 58) 4 (2, 11) 1 (0, 7) 2 (0, 6)
post_p 0.89 (0.75, 1) 0.71 (0.53, 0.85) 0.59 (0.51, 0.85) 0.6 (0.52, 0.79)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.015, 0.055) 0.023 (0, 0.075) 0 (0, 0.059) 0 (0, 0.07)
Taxel_therapies count 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 16 (16, 16) 4 (4, 4) 3 (3, 3) 4 (4, 4)
post_p 0.76 (0.76, 0.76) 0.79 (0.79, 0.79) 0.72 (0.72, 0.72) 0.64 (0.64, 0.64)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.078, 0.078) 0 (0, 0) 0 (0, 0) 0.056 (0.056, 0.056)
Carboplatin count 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 10 (10, 10) 4 (4, 4) 7 (7, 7) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.58 (0.58, 0.58) 0.77 (0.77, 0.77) 0.55 (0.55, 0.55)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.048 (0.048, 0.048) 0 (0, 0) 0.033 (0.033, 0.033) 0.247 (0.247, 0.247)
Niraparib count 3 3 3 3
time 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15)
n 14 (13, 24) 4 (2, 6) 9 (5, 10) 4 (2, 9)
post_p 0.78 (0.75, 0.84) 0.56 (0.53, 0.85) 0.78 (0.62, 0.9) 0.58 (0.55, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.043 (0.009, 0.051) 0.041 (0.008, 0.042) 0.044 (0.037, 0.05) 0.043 (0.009, 0.058)
TP53+ Hormone_therapies count 3 3 3 3 3 3 3 3
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 18 (13, 23) 5 (5, 8) 2 (0, 3) 2 (1, 3) 5 (4, 7) 5 (1, 5) 2 (0, 4) 0 (0, 0)
post_p 0.88 (0.81, 0.9) 0.72 (0.61, 0.81) 0.61 (0.57, 0.65) 0.63 (0.63, 0.67) 0.75 (0.57, 0.81) 0.54 (0.54, 0.54) 0.62 (0.56, 0.67) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.052, 0.078) 0.084 (0.064, 0.085) 0.067 (0.013, 0.121) 0 (0, 0.06) 0.1 (0.046, 0.139) 0.065 (0.013, 0.116) 0.027 (0.005, 0.049) NA (NA, NA)
Taxel_therapies count 9 9 9 9 9 9 9 9
time 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13)
n 9 (6, 13) 11 (7, 15) 0 (0, 2) 1 (0, 3) 3 (2, 5) 3 (2, 5) 1 (0, 3) 1 (0, 3)
post_p 0.76 (0.69, 0.86) 0.81 (0.67, 0.88) 0.65 (0.56, 0.75) 0.57 (0.52, 0.63) 0.57 (0.53, 0.85) 0.55 (0.51, 0.7) 0.59 (0.51, 0.72) 0.62 (0.53, 0.63)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.054, 0.116) 0.05 (0.03, 0.093) 0 (0, 0) 0 (0, 0.039) 0.081 (0, 0.142) 0.062 (0, 0.092) 0 (0, 0.078) 0 (0, 0.034)
Carboplatin count 3 3 3 3 3 3 3 3
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 14 (13, 15) 5 (2, 9) 2 (0, 3) 3 (2, 4) 2 (2, 4) 1 (1, 3) 2 (0, 4) 4 (3, 4)
post_p 0.81 (0.77, 0.89) 0.53 (0.53, 0.8) 0.63 (0.6, 0.65) 0.66 (0.57, 0.7) 0.58 (0.58, 0.62) 0.64 (0.53, 0.64) 0.59 (0.56, 0.63) 0.69 (0.63, 0.73)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.043 (0.04, 0.052) 0.091 (0.018, 0.095) 0.222 (0.112, 0.332) 0 (0, 0.09) 0.091 (0.018, 0.132) 0 (0, 0.06) 0.088 (0.068, 0.108) 0.104 (0.07, 0.153)
Niraparib count 4 4 4 4 4 4 4 4
time 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20)
n 16 (11, 22) 4 (1, 7) 3 (2, 5) 4 (1, 10) 2 (0, 3) 4 (2, 5) 3 (2, 4) 3 (1, 4)
post_p 0.9 (0.8, 0.94) 0.72 (0.58, 0.77) 0.72 (0.55, 0.79) 0.75 (0.56, 0.92) 0.67 (0.64, 0.7) 0.75 (0.61, 0.79) 0.7 (0.59, 0.82) 0.7 (0.56, 0.86)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.035, 0.067) 0.086 (0.063, 0.111) 0.107 (0.076, 0.135) 0.081 (0.018, 0.109) 0.046 (0.009, 0.082) 0.065 (0.014, 0.089) 0.092 (0.022, 0.113) 0.088 (0.018, 0.122)
DRD+ Hormone_therapies count 7 7 7 7 7 7 7 7
time 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30)
n 1 (0, 4) 1 (1, 8) 4 (3, 8) 3 (3, 7) 2 (2, 3) 3 (1, 4) 4 (1, 5) 4 (3, 9)
post_p 0.74 (0.64, 0.76) 0.84 (0.64, 0.91) 0.72 (0.62, 0.87) 0.73 (0.64, 0.84) 0.6 (0.52, 0.74) 0.65 (0.52, 0.76) 0.71 (0.6, 0.84) 0.71 (0.52, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.03 (0.007, 0.052) 0 (0, 0.057) 0.063 (0.036, 0.116) 0.057 (0.019, 0.097) 0.055 (0, 0.083) 0.09 (0.016, 0.164) 0.065 (0.047, 0.087) 0.065 (0.028, 0.108)
Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 9 (9, 9) 4 (4, 4) 2 (2, 2) 1 (1, 1) 5 (5, 5) 3 (3, 3) 0 (0, 0) 1 (1, 1)
post_p 0.82 (0.82, 0.82) 0.71 (0.71, 0.71) 0.58 (0.58, 0.58) 0.51 (0.51, 0.51) 0.88 (0.88, 0.88) 0.7 (0.7, 0.7) NA (NA, NA) 0.55 (0.55, 0.55)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.08 (0.08, 0.08) 0.049 (0.049, 0.049) 0 (0, 0) 0 (0, 0) 0.085 (0.085, 0.085) 0.057 (0.057, 0.057) NA (NA, NA) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2
time 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14)
n 4 (3, 4) 7 (5, 9) 5 (4, 6) 2 (2, 3) 5 (5, 5) 0 (0, 1) 4 (4, 4) 4 (3, 4)
post_p 0.6 (0.6, 0.62) 0.72 (0.7, 0.74) 0.84 (0.76, 0.92) 0.55 (0.51, 0.59) 0.68 (0.63, 0.73) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.59 (0.52, 0.66)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.042 (0.008, 0.076) 0.077 (0.07, 0.083) 0.012 (0.002, 0.021) 0.082 (0.016, 0.147) 0.04 (0.008, 0.072) 0.112 (0.112, 0.112) 0.098 (0.075, 0.121) 0.157 (0.07, 0.244)
TEfus+ Hormone_therapies count 10 10 10 10 10 10 10 10
time 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23)
n 5 (3, 6) 6 (5, 14) 2 (1, 4) 2 (1, 4) 2 (1, 7) 5 (2, 8) 2 (0, 4) 1 (0, 4)
post_p 0.82 (0.72, 0.9) 0.74 (0.57, 0.88) 0.73 (0.6, 0.9) 0.64 (0.5, 0.87) 0.65 (0.55, 0.78) 0.64 (0.53, 0.76) 0.57 (0.52, 0.72) 0.61 (0.56, 0.75)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.057) 0.073 (0.051, 0.109) 0 (0, 0.045) 0 (0, 0.075) 0.082 (0, 0.107) 0.076 (0, 0.114) 0.072 (0, 0.11) 0 (0, 0.074)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13)
n 2 (0, 3) 15 (12, 17) 1 (0, 4) 1 (0, 2) 3 (2, 5) 4 (2, 10) 0 (0, 0) 0 (0, 2)
post_p 0.54 (0.51, 0.56) 0.71 (0.7, 0.83) 0.63 (0.56, 0.7) 0.59 (0.52, 0.66) 0.71 (0.63, 0.71) 0.88 (0.75, 0.93) NA (NA, NA) 0.6 (0.6, 0.6)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.045 (0.009, 0.08) 0.063 (0.062, 0.072) 0 (0, 0) 0.032 (0.006, 0.058) 0.055 (0.011, 0.08) 0.068 (0.014, 0.076) NA (NA, NA) 0 (0, 0)
Carboplatin count 2 2 2 2 2 2 2 2
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 2 (1, 2) 4 (2, 5) 3 (3, 3) 4 (3, 5) 4 (3, 6) 2 (1, 4) 6 (3, 8) 4 (3, 4)
post_p 0.58 (0.52, 0.64) 0.58 (0.56, 0.59) 0.6 (0.53, 0.66) 0.72 (0.67, 0.77) 0.76 (0.74, 0.79) 0.69 (0.66, 0.72) 0.81 (0.81, 0.81) 0.65 (0.65, 0.66)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.114 (0.113, 0.115) 0.085 (0.069, 0.102) 0.018 (0.004, 0.032) 0.026 (0.005, 0.048) 0.022 (0.004, 0.039) 0.13 (0.127, 0.134) 0.048 (0.041, 0.054)
Niraparib count 3 3 3 3 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 1 (0, 3) 8 (6, 9) 4 (4, 7) 3 (1, 5) 2 (1, 3) 2 (1, 4) 3 (2, 5) 4 (4, 4)
post_p 0.52 (0.52, 0.53) 0.73 (0.59, 0.86) 0.62 (0.56, 0.79) 0.56 (0.51, 0.62) 0.64 (0.54, 0.66) 0.62 (0.58, 0.65) 0.67 (0.55, 0.67) 0.74 (0.71, 0.77)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.054 (0.034, 0.072) 0.048 (0.047, 0.056) 0.06 (0.012, 0.125) 0 (0, 0) 0 (0, 0.037) 0.101 (0.073, 0.285) 0.08 (0.016, 0.131)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3)
n 13 (13, 13) 2 (2, 2) 6 (6, 6) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.2 (0.2, 0.2) 0.34 (0.34, 0.34) 0.36 (0.36, 0.36) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.102 (0.102, 0.102) 0.292 (0.292, 0.292) 0.078 (0.078, 0.078) 0.206 (0.206, 0.206) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6)
n 6 (5, 8) 3 (3, 4) 3 (2, 10) 6 (5, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 3 (3, 4) 1 (0, 1) 1 (0, 4) 4 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.44 (0.28, 0.46) 0.45 (0.45, 0.49) 0.48 (0.16, 0.48) 0.37 (0.33, 0.47) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.46 (0.46, 0.48) 0.39 (0.31, 0.47) 0.43 (0.43, 0.43) 0.35 (0.28, 0.41) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.114 (0.083, 0.306) 0.185 (0.037, 0.192) 0.141 (0.028, 0.234) 0.128 (0.127, 0.131) 1.07 (1.07, 1.07) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.124 (0.025, 0.211) 0.143 (0.029, 0.258) 0.712 (0.187, 1.236) 0.251 (0.216, 0.285) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12)
n 6 (4, 8) 0 (0, 0) 6 (4, 8) 4 (3, 6) 5 (5, 5) 6 (5, 6) 1 (0, 2) 1 (0, 2) 2 (1, 3) 2 (1, 2) 2 (1, 3) 0 (0, 0) 2 (1, 2) 2 (0, 3) 2 (1, 4) 4 (1, 6)
post_p 0.29 (0.2, 0.38) NA (NA, NA) 0.34 (0.27, 0.41) 0.4 (0.37, 0.42) 0.22 (0.12, 0.33) 0.45 (0.41, 0.48) 0.46 (0.46, 0.46) 0.49 (0.49, 0.49) 0.45 (0.43, 0.48) 0.39 (0.31, 0.47) 0.35 (0.24, 0.46) NA (NA, NA) 0.34 (0.31, 0.37) 0.12 (0.12, 0.12) 0.33 (0.27, 0.39) 0.46 (0.46, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.161 (0.153, 0.169) NA (NA, NA) 0.227 (0.154, 0.299) 0.203 (0.154, 0.253) 0.189 (0.09, 0.288) 0.112 (0.09, 0.135) 0.08 (0.08, 0.08) 0.095 (0.095, 0.095) 0.089 (0.018, 0.161) 0.171 (0.034, 0.307) 0.25 (0.218, 0.282) NA (NA, NA) 0.209 (0.206, 0.212) 0.551 (0.551, 0.551) 0.245 (0.131, 0.359) 0.041 (0.041, 0.041)
Niraparib count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28)
n 22 (13, 70) 5 (2, 15) 10 (8, 33) 4 (2, 17) 10 (4, 18) 2 (1, 8) 3 (3, 7) 1 (1, 2) 2 (1, 4) 4 (1, 6) 3 (2, 7) 4 (2, 5) 2 (2, 4) 3 (3, 5) 2 (2, 4) 2 (2, 6)
post_p 0.06 (0.05, 0.37) 0.39 (0.38, 0.39) 0.14 (0.11, 0.43) 0.44 (0.21, 0.47) 0.33 (0.17, 0.4) 0.32 (0.32, 0.34) 0.24 (0.19, 0.34) 0.37 (0.32, 0.38) 0.41 (0.28, 0.42) 0.36 (0.35, 0.37) 0.3 (0.27, 0.45) 0.35 (0.27, 0.46) 0.19 (0.18, 0.2) 0.28 (0.24, 0.3) 0.18 (0.14, 0.43) 0.34 (0.24, 0.42)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.106 (0.103, 0.185) 0.153 (0.113, 2.178) 0.23 (0.138, 0.234) 0.122 (0.106, 1.745) 0.142 (0.105, 0.184) 0.2 (0.111, 4.306) 0.296 (0.172, 0.441) 0.326 (0.234, 0.335) 0.287 (0.183, 0.304) 0.144 (0.14, 0.148) 0.148 (0.122, 0.389) 0.178 (0.155, 0.39) 0.418 (0.226, 0.877) 0.197 (0.121, 0.394) 0.218 (0.139, 0.299) 0.267 (0.181, 0.485)
TP53- & AR- Hormone_therapies count 2 2 2 2
time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
n 24 (22, 25) 2 (2, 3) 0 (0, 1) 1 (0, 2)
post_p 0.4 (0.36, 0.45) 0.12 (0.05, 0.19) 0.49 (0.49, 0.49) 0.19 (0.19, 0.19)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.071 (0.056, 0.085) 0.766 (0.7, 0.832) 0 (0, 0) 0.177 (0.177, 0.177)
Taxel_therapies count 396 396 396 396
time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
n 19 (8, 59) 6 (3, 16) 6 (2, 15) 5 (2, 14)
post_p 0.16 (0.02, 0.41) 0.28 (0.1, 0.46) 0.35 (0.15, 0.48) 0.35 (0.17, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.086, 0.197) 0.137 (0.086, 0.317) 0.132 (0.079, 0.428) 0.127 (0.08, 0.39)
Carboplatin count 391 391 391 391
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 18 (8, 56) 5 (1, 14) 7 (3, 15) 7 (3, 15)
post_p 0.18 (0.03, 0.45) 0.34 (0.16, 0.48) 0.33 (0.13, 0.47) 0.35 (0.13, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.084, 0.182) 0.132 (0.081, 0.383) 0.126 (0.083, 0.309) 0.126 (0.081, 0.274)
Niraparib count 382 382 382 382
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 18 (8, 59) 5 (2, 15) 7 (2, 15) 7 (3, 16)
post_p 0.18 (0.03, 0.45) 0.33 (0.13, 0.47) 0.33 (0.1, 0.48) 0.33 (0.13, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.083, 0.19) 0.138 (0.082, 0.428) 0.132 (0.088, 0.34) 0.129 (0.081, 0.34)
TP53+ Hormone_therapies count 29 29 29 29 29 29 29 29
time 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29)
n 14 (6, 29) 8 (3, 15) 2 (0, 3) 2 (1, 5) 3 (1, 7) 3 (1, 7) 2 (0, 4) 2 (1, 4)
post_p 0.28 (0.09, 0.42) 0.36 (0.12, 0.48) 0.33 (0.18, 0.49) 0.42 (0.28, 0.47) 0.31 (0.22, 0.44) 0.32 (0.18, 0.49) 0.35 (0.15, 0.47) 0.34 (0.21, 0.47)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.146 (0.112, 0.236) 0.157 (0.091, 0.344) 0.239 (0.117, 0.493) 0.17 (0.044, 1.247) 0.227 (0.142, 1.247) 0.196 (0.104, 0.456) 0.416 (0.075, 0.955) 0.228 (0.094, 1.164)
Taxel_therapies count 29 29 29 29 29 29 29 29
time 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33)
n 11 (5, 27) 10 (5, 16) 2 (0, 5) 2 (0, 4) 4 (1, 11) 4 (2, 8) 2 (0, 5) 2 (1, 5)
post_p 0.34 (0.17, 0.46) 0.25 (0.13, 0.43) 0.31 (0.19, 0.43) 0.4 (0.28, 0.49) 0.38 (0.19, 0.46) 0.35 (0.14, 0.48) 0.33 (0.21, 0.45) 0.36 (0.22, 0.49)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.143 (0.103, 0.246) 0.15 (0.108, 0.197) 0.292 (0.148, 0.545) 0.18 (0.108, 0.793) 0.174 (0.124, 0.523) 0.137 (0.07, 0.462) 0.205 (0.02, 0.733) 0.196 (0.107, 0.78)
Carboplatin count 35 35 35 35 35 35 35 35
time 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35)
n 11 (6, 20) 6 (2, 13) 3 (1, 7) 4 (2, 8) 3 (2, 11) 3 (1, 8) 2 (1, 8) 3 (1, 6)
post_p 0.28 (0.09, 0.47) 0.33 (0.16, 0.47) 0.34 (0.19, 0.48) 0.41 (0.26, 0.49) 0.35 (0.19, 0.49) 0.35 (0.13, 0.47) 0.38 (0.19, 0.49) 0.34 (0.14, 0.46)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.11, 0.227) 0.143 (0.104, 0.516) 0.207 (0.122, 1.072) 0.155 (0.097, 0.268) 0.151 (0.095, 0.33) 0.198 (0.1, 0.814) 0.168 (0.094, 1.099) 0.247 (0.095, 0.766)
Niraparib count 30 30 30 30 30 30 30 30
time 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33)
n 10 (5, 40) 6 (4, 19) 3 (1, 8) 2 (1, 9) 3 (0, 7) 3 (1, 5) 3 (2, 6) 3 (1, 7)
post_p 0.24 (0.12, 0.49) 0.38 (0.16, 0.46) 0.35 (0.18, 0.47) 0.33 (0.22, 0.48) 0.35 (0.23, 0.46) 0.38 (0.24, 0.48) 0.4 (0.22, 0.49) 0.35 (0.15, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.159 (0.114, 0.416) 0.131 (0.1, 0.333) 0.166 (0.108, 1.105) 0.234 (0.116, 0.635) 0.168 (0.13, 0.55) 0.184 (0.12, 0.664) 0.181 (0.109, 0.324) 0.165 (0.093, 0.544)
DRD+ Hormone_therapies count 2 2 2 2 2 2 2 2
time 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27)
n 0 (0, 1) 2 (2, 2) 4 (3, 4) 7 (6, 8) 3 (2, 4) 1 (1, 1) 2 (1, 4) 6 (5, 8)
post_p 0.42 (0.42, 0.42) 0.43 (0.41, 0.44) 0.24 (0.2, 0.28) 0.28 (0.22, 0.35) 0.27 (0.27, 0.28) 0.43 (0.38, 0.48) 0.27 (0.22, 0.32) 0.42 (0.35, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.123 (0.123, 0.123) 0.11 (0.108, 0.112) 0.241 (0.21, 0.272) 0.116 (0.105, 0.128) 0.362 (0.305, 0.419) 0.423 (0.246, 0.6) 5.716 (1.253, 10.18) 0.124 (0.079, 0.17)
Taxel_therapies count 40 40 40 40 40 40 40 40
time 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34)
n 6 (2, 17) 5 (2, 10) 2 (1, 5) 2 (0, 5) 4 (1, 8) 3 (1, 6) 2 (1, 8) 2 (1, 5)
post_p 0.32 (0.19, 0.45) 0.31 (0.17, 0.45) 0.35 (0.18, 0.46) 0.34 (0.21, 0.48) 0.36 (0.19, 0.47) 0.38 (0.28, 0.48) 0.36 (0.25, 0.48) 0.38 (0.26, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.088, 0.226) 0.129 (0.087, 0.253) 0.204 (0.108, 0.612) 0.243 (0.125, 1.44) 0.187 (0.133, 0.446) 0.164 (0.106, 0.534) 0.168 (0.109, 0.709) 0.217 (0.117, 0.516)
Carboplatin count 41 41 41 41 41 41 41 41
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 7 (2, 14) 7 (3, 14) 3 (2, 7) 3 (1, 6) 4 (1, 8) 3 (1, 8) 5 (2, 8) 4 (1, 7)
post_p 0.38 (0.14, 0.46) 0.3 (0.12, 0.43) 0.33 (0.18, 0.46) 0.37 (0.22, 0.45) 0.35 (0.23, 0.47) 0.38 (0.19, 0.47) 0.38 (0.13, 0.48) 0.36 (0.15, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.087, 0.328) 0.13 (0.089, 0.243) 0.2 (0.104, 1.192) 0.203 (0.104, 0.4) 0.161 (0.107, 0.608) 0.149 (0.102, 0.597) 0.154 (0.101, 0.278) 0.195 (0.091, 0.593)
Niraparib count 42 42 42 42 42 42 42 42
time 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34)
n 5 (2, 14) 6 (3, 18) 4 (1, 9) 3 (1, 7) 4 (1, 6) 4 (1, 8) 4 (2, 6) 4 (2, 8)
post_p 0.29 (0.13, 0.42) 0.29 (0.13, 0.47) 0.38 (0.19, 0.46) 0.32 (0.18, 0.48) 0.33 (0.21, 0.44) 0.34 (0.2, 0.46) 0.36 (0.18, 0.48) 0.38 (0.2, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.088, 0.491) 0.134 (0.088, 0.374) 0.2 (0.117, 0.683) 0.247 (0.108, 1.097) 0.174 (0.115, 0.344) 0.187 (0.102, 0.662) 0.183 (0.091, 0.489) 0.161 (0.107, 0.372)
TEfus+ Hormone_therapies count 3 3 3 3 3 3 3 3
time 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28)
n 4 (2, 4) 9 (5, 18) 1 (0, 2) 2 (1, 2) 4 (3, 8) 3 (2, 5) 4 (3, 4) 2 (1, 4)
post_p 0.36 (0.35, 0.4) 0.22 (0.18, 0.39) 0.44 (0.39, 0.49) 0.34 (0.25, 0.42) 0.38 (0.18, 0.46) 0.46 (0.25, 0.47) 0.42 (0.28, 0.43) 0.36 (0.31, 0.44)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.091, 0.141) 0.153 (0.107, 0.333) 0.12 (0.103, 0.137) 0.827 (0.387, 0.924) 0.169 (0.143, 0.272) 0.211 (0.156, 0.542) 0.151 (0.11, 0.227) 0.166 (0.11, 3.035)
Taxel_therapies count 48 48 48 48 48 48 48 48
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 4 (2, 12) 10 (5, 21) 4 (1, 9) 2 (0, 5) 5 (3, 10) 5 (2, 10) 2 (0, 7) 2 (0, 4)
post_p 0.31 (0.13, 0.45) 0.32 (0.1, 0.47) 0.33 (0.12, 0.45) 0.35 (0.25, 0.48) 0.39 (0.23, 0.48) 0.34 (0.16, 0.47) 0.35 (0.24, 0.47) 0.35 (0.2, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.161 (0.077, 0.337) 0.146 (0.111, 0.238) 0.164 (0.106, 0.568) 0.188 (0.111, 1.131) 0.137 (0.104, 0.346) 0.15 (0.101, 0.458) 0.19 (0.105, 0.643) 0.195 (0.079, 0.768)
Carboplatin count 42 42 42 42 42 42 42 42
time 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35)
n 4 (1, 9) 6 (4, 16) 6 (2, 11) 4 (1, 6) 3 (1, 7) 3 (1, 8) 3 (1, 7) 3 (1, 7)
post_p 0.3 (0.18, 0.45) 0.34 (0.16, 0.47) 0.35 (0.14, 0.47) 0.35 (0.19, 0.47) 0.37 (0.24, 0.46) 0.35 (0.2, 0.45) 0.36 (0.23, 0.48) 0.37 (0.17, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.151 (0.076, 0.416) 0.157 (0.107, 0.311) 0.126 (0.086, 0.255) 0.155 (0.115, 0.539) 0.168 (0.096, 0.699) 0.185 (0.119, 0.786) 0.181 (0.108, 0.615) 0.173 (0.105, 0.318)
Niraparib count 30 30 30 30 30 30 30 30
time 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34)
n 4 (1, 14) 8 (4, 22) 5 (3, 10) 3 (1, 7) 3 (1, 6) 4 (2, 8) 4 (1, 8) 4 (1, 8)
post_p 0.37 (0.13, 0.45) 0.38 (0.15, 0.48) 0.25 (0.13, 0.46) 0.38 (0.18, 0.48) 0.37 (0.22, 0.47) 0.4 (0.19, 0.49) 0.33 (0.16, 0.49) 0.34 (0.22, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.085, 0.747) 0.14 (0.102, 0.285) 0.155 (0.095, 0.413) 0.176 (0.11, 0.449) 0.206 (0.118, 0.654) 0.171 (0.095, 0.338) 0.136 (0.091, 1.132) 0.164 (0.096, 0.579)