Simulation scenario 4

Setting description

Hormone_therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 35 4 2 2 TP53- & AR- 405 1 1 3 TP53+ 3 9 3 4 DRD+ 7 0 1 2 TEfus+ 10 3 2 3

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.070 0.008 0.004 0.004 TP53- & AR- 0.810 0.002 0.002 0.006 TP53+ 0.006 0.018 0.006 0.008 DRD+ 0.014 0.000 0.002 0.004 TEfus+ 0.020 0.006 0.004 0.006

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 1 3 2 3 TP53- & AR- 2 396 391 382 TP53+ 29 29 35 30 DRD+ 2 40 41 42 TEfus+ 3 48 42 30

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.002 0.006 0.004 0.006 TP53- & AR- 0.004 0.792 0.782 0.764 TP53+ 0.058 0.058 0.070 0.060 DRD+ 0.004 0.080 0.082 0.084 TEfus+ 0.006 0.096 0.084 0.060

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 49 11 16 27 TP53+ 10 12 8 9 DRD+ 0 0 0 0 TEfus+ 0 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.098 0.022 0.032 0.054 TP53+ 0.020 0.024 0.016 0.018 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000

Errors & power

The overall error was 0.132.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.062             0.034             0.016             0.028 

The overall power was 0.81.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.81              0.00              0.00              0.00 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	35	4	2	2
	futility	0	1	3	2	3
	max_n	0	0	0	0	0
	n	418 (351, 460)	158 (95, 262)	168 (120, 246)	166 (119, 235)	167 (122, 252)
	n_unique	386 (324, 426)	145 (88, 246)	155 (111, 230)	152 (109, 219)	155 (111, 237)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	4 (3, 6)	6 (4, 6)	7 (6, 11)	22 (6, 28)
	post_p	NA (NA, NA)	0.97 (0.64, 1)	0.04 (0, 0.29)	0.05 (0, 0.29)	0.05 (0, 0.34)
	rate	0.094 (0.087, 0.102)	0.078 (0.06, 0.09)	0.113 (0.102, 0.128)	0.113 (0.102, 0.126)	0.112 (0.101, 0.126)
TP53- & AR-	graduation	0	405	1	1	3
	futility	0	2	396	391	382
	max_n	0	49	11	16	27
	n	177 (109, 206)	34 (25, 150)	41 (25, 120)	44 (26, 122)	46 (25, 134)
	n_unique	165 (98, 193)	32 (24, 141)	36 (23, 111)	40 (23, 114)	42 (23, 127)
	time_trial	36 (36, 36)	10 (7, 36)	25 (14, 36)	23 (14, 36)	24 (14, 36)
	time_stop	NA (NA, NA)	9 (6, 20)	21 (13, 33)	20 (13, 31)	21 (13, 32)
	post_p	NA (NA, NA)	1 (0.97, 1)	0.01 (0, 0.12)	0.01 (0, 0.15)	0.02 (0, 0.12)
	rate	0.075 (0.064, 0.084)	0.041 (0.031, 0.051)	0.116 (0.098, 0.152)	0.115 (0.095, 0.143)	0.114 (0.097, 0.145)
TP53+	graduation	0	3	9	3	4
	futility	0	29	29	35	30
	max_n	0	10	12	8	9
	n	184 (162, 210)	84 (33, 122)	89 (53, 127)	82 (54, 119)	86 (51, 126)
	n_unique	170 (148, 194)	76 (31, 114)	81 (49, 118)	76 (49, 111)	79 (47, 117)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	19 (11, 29)	15 (8, 31)	20 (13, 35)	19 (11, 32)
	post_p	NA (NA, NA)	0.52 (0.09, 0.89)	0.53 (0.11, 0.9)	0.49 (0.1, 0.9)	0.51 (0.1, 0.88)
	rate	0.113 (0.101, 0.124)	0.112 (0.096, 0.137)	0.112 (0.097, 0.135)	0.113 (0.097, 0.138)	0.113 (0.097, 0.135)
DRD+	graduation	0	7	0	1	2
	futility	0	2	40	41	42
	max_n	0	0	0	0	0
	n	112 (92, 128)	37 (18, 58)	47 (26, 70)	58 (39, 81)	58 (37, 80)
	n_unique	102 (84, 118)	33 (17, 53)	43 (24, 65)	53 (35, 74)	53 (33, 73)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	26 (20, 29)	26 (20, 34)	24 (15, 34)	24 (14, 34)
	post_p	NA (NA, NA)	0.62 (0.18, 0.95)	0.26 (0.04, 0.71)	0.2 (0.02, 0.67)	0.19 (0.02, 0.68)
	rate	0.097 (0.083, 0.113)	0.091 (0.068, 0.125)	0.112 (0.093, 0.146)	0.114 (0.094, 0.141)	0.115 (0.096, 0.143)
TEfus+	graduation	0	10	3	2	3
	futility	0	3	48	42	30
	max_n	0	0	0	0	0
	n	151 (127, 173)	59 (28, 88)	71 (42, 100)	68 (42, 97)	69 (45, 98)
	n_unique	138 (117, 158)	55 (26, 80)	66 (39, 92)	62 (39, 89)	64 (40, 90)
	time_trial	36 (36, 36)	36 (36, 36)	36 (35, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	16 (12, 28)	20 (11, 32)	20 (15, 35)	21 (14, 34)
	post_p	NA (NA, NA)	0.72 (0.24, 0.97)	0.24 (0.04, 0.7)	0.27 (0.04, 0.73)	0.27 (0.03, 0.68)
	rate	0.1 (0.088, 0.113)	0.092 (0.072, 0.115)	0.114 (0.097, 0.139)	0.113 (0.096, 0.135)	0.112 (0.096, 0.139)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	439	404	396	387
	futility	0	0	0	0	0
	max_n	0	49	11	16	27
	n	114 (70, 136)	27 (19, 107)	21 (8, 76)	19 (8, 74)	22 (8, 83)
	n_unique	106 (62, 128)	25 (17, 103)	19 (7, 72)	18 (7, 71)	20 (7, 79)
	post_p	NA (NA, NA)	1 (0.93, 1)	0.06 (0.01, 0.3)	0.08 (0.01, 0.31)	0.07 (0, 0.32)
	rate	0.074 (0.064, 0.087)	0.041 (0.03, 0.053)	0.119 (0.093, 0.183)	0.117 (0.09, 0.173)	0.116 (0.09, 0.18)
—+	graduation	0	439	409	403	389
	futility	0	0	0	0	0
	max_n	0	49	11	16	27
	n	20 (12, 28)	4 (2, 14)	7 (3, 17)	6 (2, 17)	6 (2, 19)
	n_unique	18 (10, 26)	4 (1, 13)	6 (2, 16)	5 (1, 16)	6 (2, 17)
	post_p	NA (NA, NA)	0.83 (0.45, 0.98)	0.24 (0.08, 0.52)	0.3 (0.12, 0.61)	0.27 (0.09, 0.57)
	rate	0.076 (0.051, 0.11)	0.044 (0.018, 0.096)	0.136 (0.083, 0.299)	0.127 (0.075, 0.328)	0.127 (0.077, 0.342)
–+-	graduation	0	68	45	41	36
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	62 (49, 77)	26 (8, 56)	26 (8, 57)	22 (7, 52)	24 (6, 54)
	n_unique	57 (45, 72)	24 (7, 52)	23 (7, 54)	20 (6, 50)	22 (5, 50)
	post_p	NA (NA, NA)	0.46 (0.1, 0.87)	0.45 (0.12, 0.88)	0.43 (0.11, 0.85)	0.42 (0.11, 0.86)
	rate	0.112 (0.094, 0.136)	0.118 (0.09, 0.191)	0.117 (0.088, 0.202)	0.12 (0.092, 0.206)	0.118 (0.091, 0.211)
–++	graduation	0	79	88	76	66
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	41 (32, 53)	17 (4, 36)	18 (7, 41)	14 (4, 34)	14 (5, 35)
	n_unique	38 (29, 50)	15 (3, 34)	17 (6, 39)	12 (3, 31)	14 (4, 33)
	post_p	NA (NA, NA)	0.49 (0.15, 0.87)	0.48 (0.13, 0.87)	0.45 (0.15, 0.85)	0.44 (0.14, 0.83)
	rate	0.113 (0.09, 0.143)	0.119 (0.082, 0.227)	0.117 (0.089, 0.195)	0.119 (0.085, 0.276)	0.121 (0.086, 0.228)
-+–	graduation	0	439	407	401	394
	futility	0	0	0	0	0
	max_n	0	49	11	16	26
	n	19 (11, 27)	2 (0, 11)	7 (2, 17)	8 (3, 20)	8 (3, 19)
	n_unique	18 (10, 25)	1 (0, 11)	6 (1, 16)	7 (3, 18)	7 (2, 18)
	post_p	NA (NA, NA)	0.78 (0.42, 0.96)	0.3 (0.11, 0.62)	0.25 (0.09, 0.58)	0.27 (0.09, 0.58)
	rate	0.076 (0.052, 0.11)	0.043 (0, 0.129)	0.126 (0.078, 0.363)	0.126 (0.079, 0.281)	0.127 (0.08, 0.301)
-+-+	graduation	0	439	412	407	395
	futility	0	0	0	0	0
	max_n	0	49	11	16	26
	n	20 (12, 28)	2 (0, 11)	6 (2, 18)	8 (3, 19)	8 (3, 20)
	n_unique	18 (11, 26)	2 (0, 11)	5 (2, 17)	7 (3, 17)	7 (3, 18)
	post_p	NA (NA, NA)	0.75 (0.4, 0.96)	0.3 (0.11, 0.6)	0.26 (0.1, 0.58)	0.25 (0.08, 0.56)
	rate	0.074 (0.052, 0.109)	0.049 (0.015, 0.135)	0.125 (0.078, 0.308)	0.122 (0.081, 0.259)	0.129 (0.085, 0.302)
-++-	graduation	0	77	76	74	71
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	12 (7, 17)	4 (1, 11)	4 (1, 11)	6 (2, 13)	6 (2, 12)
	n_unique	11 (7, 16)	4 (1, 10)	4 (1, 10)	5 (2, 12)	6 (2, 11)
	post_p	NA (NA, NA)	0.47 (0.22, 0.82)	0.45 (0.23, 0.81)	0.46 (0.2, 0.8)	0.44 (0.21, 0.82)
	rate	0.117 (0.073, 0.179)	0.13 (0.063, 0.45)	0.132 (0.066, 0.418)	0.135 (0.074, 0.391)	0.131 (0.071, 0.323)
-+++	graduation	0	88	113	102	97
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	12 (7, 18)	4 (1, 10)	4 (1, 10)	6 (2, 13)	6 (2, 13)
	n_unique	11 (6, 16)	4 (1, 9)	4 (1, 9)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.47 (0.23, 0.82)	0.46 (0.22, 0.82)	0.44 (0.23, 0.82)	0.44 (0.2, 0.84)
	rate	0.118 (0.078, 0.175)	0.129 (0.065, 0.383)	0.132 (0.068, 0.431)	0.139 (0.07, 0.322)	0.137 (0.072, 0.396)
+—	graduation	0	36	7	4	5
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 27)	8 (2, 18)	10 (4, 20)	8 (3, 17)	8 (2, 18)
	n_unique	18 (12, 25)	7 (2, 17)	9 (3, 19)	7 (3, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.48 (0.2, 0.84)	0.45 (0.15, 0.83)	0.48 (0.19, 0.85)	0.44 (0.19, 0.85)
	rate	0.113 (0.085, 0.169)	0.125 (0.074, 0.265)	0.124 (0.08, 0.305)	0.12 (0.075, 0.283)	0.125 (0.075, 0.308)
+–+	graduation	0	49	58	48	36
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	16 (10, 22)	6 (2, 15)	8 (3, 17)	6 (2, 15)	6 (2, 15)
	n_unique	15 (10, 21)	6 (1, 14)	7 (2, 15)	6 (2, 14)	6 (2, 14)
	post_p	NA (NA, NA)	0.45 (0.2, 0.82)	0.43 (0.17, 0.85)	0.47 (0.21, 0.83)	0.46 (0.21, 0.83)
	rate	0.114 (0.083, 0.162)	0.128 (0.075, 0.334)	0.13 (0.079, 0.321)	0.124 (0.07, 0.343)	0.127 (0.071, 0.392)
+-+-	graduation	0	68	45	41	36
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	16 (11, 23)	6 (2, 14)	8 (3, 16)	6 (2, 14)	7 (2, 15)
	n_unique	15 (9, 21)	5 (1, 13)	7 (3, 16)	5 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.43 (0.2, 0.81)	0.45 (0.19, 0.82)	0.48 (0.21, 0.84)	0.48 (0.22, 0.84)
	rate	0.116 (0.081, 0.17)	0.133 (0.073, 0.34)	0.127 (0.081, 0.281)	0.122 (0.071, 0.332)	0.125 (0.07, 0.293)
+-++	graduation	0	79	88	76	66
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	16 (10, 22)	6 (1, 15)	7 (2, 17)	6 (2, 15)	6 (2, 14)
	n_unique	14 (10, 20)	5 (1, 13)	7 (2, 16)	6 (2, 14)	6 (2, 14)
	post_p	NA (NA, NA)	0.44 (0.2, 0.8)	0.45 (0.19, 0.81)	0.49 (0.21, 0.83)	0.48 (0.2, 0.82)
	rate	0.113 (0.081, 0.166)	0.127 (0.074, 0.392)	0.128 (0.081, 0.312)	0.122 (0.073, 0.362)	0.122 (0.068, 0.358)
++–	graduation	0	45	47	45	47
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	4 (1, 10)	4 (1, 10)	6 (2, 13)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 10)	6 (2, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.46 (0.23, 0.8)	0.46 (0.22, 0.78)	0.49 (0.21, 0.83)	0.45 (0.19, 0.83)
	rate	0.116 (0.074, 0.181)	0.13 (0.067, 0.381)	0.129 (0.068, 0.39)	0.123 (0.069, 0.339)	0.133 (0.073, 0.383)
++-+	graduation	0	58	91	77	73
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 17)	4 (1, 10)	4 (1, 11)	6 (2, 13)	6 (2, 13)
	n_unique	10 (6, 16)	3 (1, 9)	4 (1, 10)	5 (2, 12)	6 (2, 13)
	post_p	NA (NA, NA)	0.46 (0.22, 0.8)	0.46 (0.23, 0.82)	0.47 (0.2, 0.82)	0.47 (0.21, 0.85)
	rate	0.116 (0.075, 0.177)	0.132 (0.07, 0.493)	0.132 (0.07, 0.428)	0.128 (0.074, 0.373)	0.125 (0.07, 0.392)
+++-	graduation	0	77	76	74	71
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	11 (7, 17)	4 (1, 10)	4 (1, 11)	6 (2, 12)	6 (2, 13)
	n_unique	10 (6, 16)	4 (1, 9)	4 (1, 10)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.48 (0.21, 0.82)	0.46 (0.24, 0.83)	0.45 (0.2, 0.83)	0.44 (0.2, 0.81)
	rate	0.111 (0.074, 0.176)	0.124 (0.065, 0.421)	0.127 (0.063, 0.503)	0.126 (0.07, 0.333)	0.131 (0.074, 0.388)
++++	graduation	0	88	113	102	97
	futility	0	0	0	0	0
	max_n	0	10	12	8	9
	n	12 (7, 17)	4 (1, 11)	4 (1, 11)	6 (2, 13)	6 (2, 12)
	n_unique	11 (7, 16)	4 (1, 10)	4 (1, 10)	5 (2, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.44 (0.23, 0.81)	0.47 (0.23, 0.81)	0.43 (0.19, 0.85)	0.46 (0.2, 0.81)
	rate	0.115 (0.073, 0.175)	0.131 (0.065, 0.438)	0.127 (0.062, 0.422)	0.132 (0.07, 0.359)	0.125 (0.071, 0.382)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	35	4	2	2
	time_stop	4 (3, 7)	6 (5, 7)	6 (6, 7)	6 (5, 8)
	n_trt	29 (26, 49)	38 (28, 43)	28 (26, 30)	31 (28, 34)
	n_control	49 (40, 71)	70 (52, 78)	76 (68, 84)	67 (56, 78)
	post_p	0.94 (0.88, 0.98)	0.92 (0.9, 0.95)	0.98 (0.98, 0.98)	0.91 (0.88, 0.95)
	order	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 1)
TP53- & AR-	count	405	1	1	3
	time_stop	9 (6, 21)	11 (11, 11)	8 (8, 8)	13 (10, 15)
	n_trt	33 (26, 79)	27 (27, 27)	25 (25, 25)	26 (25, 48)
	n_control	41 (28, 104)	37 (37, 37)	37 (37, 37)	58 (39, 79)
	post_p	0.95 (0.87, 1)	0.96 (0.96, 0.96)	0.85 (0.85, 0.85)	0.9 (0.88, 0.95)
	order	1 (1, 1)	1 (1, 1)	2 (2, 2)	2 (1.2, 2)
TP53+	count	3	9	3	4
	time_stop	12 (10, 14)	9 (7, 13)	11 (9, 13)	16 (10, 20)
	n_trt	42 (30, 46)	29 (26, 40)	33 (28, 40)	40 (29, 52)
	n_control	44 (35, 70)	42 (31, 71)	57 (43, 59)	70 (47, 90)
	post_p	0.94 (0.94, 0.97)	0.96 (0.91, 0.98)	0.97 (0.89, 0.99)	0.98 (0.94, 1)
	order	2 (1.2, 2)	1 (1, 2.2)	2 (1.2, 2)	1.5 (1, 2)
DRD+	count	7		1	2
	time_stop	26 (20, 30)		10 (10, 10)	12 (9, 14)
	n_trt	26 (25, 34)		25 (25, 25)	31 (27, 35)
	n_control	80 (55, 86)		29 (29, 29)	36 (30, 42)
	post_p	0.95 (0.93, 0.99)		0.92 (0.92, 0.92)	0.9 (0.88, 0.91)
	order	2 (2, 2.4)		2 (2, 2)	1 (1, 1)
TEfus+	count	10	3	2	3
	time_stop	15 (12, 23)	11 (8, 13)	12 (10, 14)	12 (11, 13)
	n_trt	28 (25, 36)	25 (25, 35)	28 (27, 29)	29 (28, 29)
	n_control	56 (43, 85)	46 (30, 54)	58 (47, 70)	45 (39, 50)
	post_p	0.98 (0.93, 1)	0.94 (0.89, 0.94)	0.96 (0.96, 0.96)	0.92 (0.9, 0.92)
	order	2 (2, 2.1)	2 (1.2, 2)	2.5 (2.1, 2.9)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	1	3	2	3
	time_stop	3 (3, 3)	5 (3, 6)	10 (8, 12)	28 (23, 28)
	n_trt	26 (26, 26)	28 (26, 38)	44 (29, 58)	107 (85, 167)
	n_control	31 (31, 31)	56 (38, 63)	105 (84, 126)	332 (268, 347)
	post_p	0.15 (0.15, 0.15)	0.08 (0.06, 0.17)	0.02 (0.01, 0.04)	0 (0, 0.01)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	4 (2.4, 6.4)
TP53- & AR-	count	2	396	391	382
	time_stop	6 (6, 7)	21 (13, 33)	20 (13, 31)	21 (13, 32)
	n_trt	28 (26, 29)	36 (25, 94)	38 (26, 87)	35 (25, 96)
	n_control	33 (32, 34)	107 (57, 178)	101 (59, 165)	104 (58, 174)
	post_p	0.15 (0.13, 0.18)	0.05 (0, 0.2)	0.06 (0, 0.2)	0.05 (0, 0.18)
	order	1 (1, 1)	2 (1, 4)	2 (1, 3)	2 (1, 4)
TP53+	count	29	29	35	30
	time_stop	20 (11, 29)	22 (9, 33)	20 (13, 35)	19 (12, 33)
	n_trt	34 (27, 62)	37 (26, 76)	38 (26, 61)	36 (26, 67)
	n_control	95 (40, 148)	107 (44, 164)	101 (60, 181)	94 (53, 170)
	post_p	0.04 (0, 0.19)	0.06 (0, 0.16)	0.05 (0.01, 0.14)	0.05 (0.01, 0.15)
	order	2 (1, 4)	2 (1, 5)	2 (1, 5)	3 (1, 5)
DRD+	count	2	40	41	42
	time_stop	26 (24, 27)	26 (20, 34)	24 (16, 34)	26 (14, 34)
	n_trt	26 (25, 27)	29 (25, 44)	39 (27, 54)	36 (26, 52)
	n_control	82 (78, 86)	78 (55, 114)	70 (45, 105)	78 (42, 106)
	post_p	0.04 (0.02, 0.07)	0.04 (0, 0.17)	0.04 (0.01, 0.14)	0.04 (0.01, 0.1)
	order	3.5 (2.3, 4.7)	4 (1, 5)	3 (2, 5)	3 (1, 5)
TEfus+	count	3	48	42	30
	time_stop	26 (19, 28)	20 (12, 32)	20 (15, 35)	22 (16, 34)
	n_trt	29 (27, 36)	38 (26, 63)	36 (26, 58)	42 (28, 60)
	n_control	121 (72, 126)	81 (41, 138)	90 (56, 148)	88 (54, 140)
	post_p	0.12 (0.05, 0.14)	0.04 (0.01, 0.15)	0.05 (0.01, 0.12)	0.05 (0.01, 0.19)
	order	3 (1.4, 3.8)	2.5 (1, 4.3)	3 (1, 5)	3 (1, 6.1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	35	35	35	35	35	35	35	35	35	35	35	35	35	35	35	35
		time	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)
		n	15 (12, 22)	2 (1, 6)	6 (3, 10)	2 (0, 7)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 2)	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
		post_p	0.76 (0.64, 0.9)	0.63 (0.54, 0.71)	0.65 (0.54, 0.77)	0.59 (0.52, 0.73)	0.54 (0.51, 0.58)	0.54 (0.53, 0.57)	0.54 (0.51, 0.56)	0.51 (0.51, 0.61)	0.6 (0.53, 0.69)	0.57 (0.51, 0.69)	0.58 (0.51, 0.64)	0.59 (0.52, 0.67)	NA (NA, NA)	0.52 (0.51, 0.52)	0.52 (0.51, 0.55)	0.52 (0.51, 0.54)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.023 (0, 0.048)	0 (0, 0.025)	0.05 (0, 0.134)	0 (0, 0.083)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.094)	0 (0, 0.108)	0 (0, 0.54)	0 (0, 0)	0 (0, 0)	0 (0, 0.205)	0 (0, 0)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
		n	4 (2, 8)	2 (0, 4)	6 (3, 9)	6 (4, 7)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	6 (4, 6)	3 (2, 3)	3 (2, 4)	4 (2, 5)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)
		post_p	0.56 (0.54, 0.65)	0.59 (0.52, 0.66)	0.74 (0.66, 0.89)	0.66 (0.56, 0.72)	0.54 (0.52, 0.55)	0.57 (0.55, 0.58)	0.59 (0.59, 0.59)	0.51 (0.51, 0.51)	0.63 (0.54, 0.66)	0.64 (0.53, 0.75)	0.73 (0.61, 0.81)	0.59 (0.52, 0.73)	0.56 (0.56, 0.56)	0.51 (0.51, 0.51)	NA (NA, NA)	0.52 (0.52, 0.52)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.023 (0, 0.088)	0 (0, 0)	0 (0, 0.03)	0.019 (0, 0.067)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.096 (0.056, 0.172)	0.108 (0.032, 0.138)	0 (0, 0.033)	0.041 (0, 0.113)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
		n	4 (3, 4)	1 (1, 1)	3 (1, 5)	0 (0, 0)	4 (4, 4)	0 (0, 1)	2 (2, 3)	2 (2, 2)	0 (0, 1)	2 (1, 4)	2 (2, 3)	1 (1, 1)	2 (2, 2)	1 (0, 2)	1 (0, 2)	2 (1, 2)
		post_p	0.59 (0.57, 0.6)	0.56 (0.56, 0.56)	0.59 (0.54, 0.64)	NA (NA, NA)	0.72 (0.71, 0.73)	0.57 (0.57, 0.57)	0.52 (0.52, 0.52)	0.56 (0.53, 0.58)	0.5 (0.5, 0.5)	0.53 (0.52, 0.53)	0.63 (0.58, 0.68)	0.51 (0.5, 0.52)	0.77 (0.76, 0.78)	0.51 (0.51, 0.51)	0.76 (0.76, 0.76)	0.63 (0.58, 0.68)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.037 (0.007, 0.066)	NA (NA, NA)	0.031 (0.006, 0.056)	0 (0, 0)	0.043 (0.009, 0.078)	0.152 (0.03, 0.273)	0 (0, 0)	0.074 (0.015, 0.133)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)
		n	2 (1, 3)	0 (0, 1)	6 (4, 8)	1 (1, 1)	2 (1, 3)	2 (2, 3)	3 (3, 3)	2 (2, 2)	2 (1, 3)	0 (0, 0)	0 (0, 1)	0 (0, 1)	2 (1, 3)	3 (2, 4)	2 (1, 2)	2 (2, 3)
		post_p	0.58 (0.55, 0.6)	0.56 (0.56, 0.56)	0.51 (0.51, 0.52)	0.54 (0.52, 0.56)	0.62 (0.57, 0.67)	0.63 (0.59, 0.66)	0.73 (0.71, 0.75)	0.6 (0.56, 0.64)	0.56 (0.54, 0.59)	NA (NA, NA)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	0.63 (0.59, 0.66)	0.62 (0.62, 0.62)	0.57 (0.54, 0.59)	0.65 (0.6, 0.71)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.096 (0.083, 0.108)	0 (0, 0)	0 (0, 0)	0.057 (0.011, 0.102)	0.061 (0.012, 0.111)	0.065 (0.013, 0.117)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.096 (0.019, 0.173)	0.078 (0.016, 0.14)	0.024 (0.005, 0.043)
TP53- & AR-	Hormone_therapies	count	405	405			405	405
		time	9 (6, 21)	9 (6, 21)			9 (6, 21)	9 (6, 21)
		n	26 (20, 58)	4 (2, 11)			1 (0, 7)	2 (0, 6)
		post_p	0.89 (0.75, 1)	0.71 (0.53, 0.85)			0.59 (0.51, 0.85)	0.6 (0.52, 0.79)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.038 (0.015, 0.055)	0.023 (0, 0.075)			0 (0, 0.059)	0 (0, 0.07)
	Taxel_therapies	count	1	1			1	1
		time	11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n	16 (16, 16)	4 (4, 4)			3 (3, 3)	4 (4, 4)
		post_p	0.76 (0.76, 0.76)	0.79 (0.79, 0.79)			0.72 (0.72, 0.72)	0.64 (0.64, 0.64)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.078 (0.078, 0.078)	0 (0, 0)			0 (0, 0)	0.056 (0.056, 0.056)
	Carboplatin	count	1	1			1	1
		time	8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n	10 (10, 10)	4 (4, 4)			7 (7, 7)	4 (4, 4)
		post_p	0.73 (0.73, 0.73)	0.58 (0.58, 0.58)			0.77 (0.77, 0.77)	0.55 (0.55, 0.55)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.048 (0.048, 0.048)	0 (0, 0)			0.033 (0.033, 0.033)	0.247 (0.247, 0.247)
	Niraparib	count	3	3			3	3
		time	13 (10, 15)	13 (10, 15)			13 (10, 15)	13 (10, 15)
		n	14 (13, 24)	4 (2, 6)			9 (5, 10)	4 (2, 9)
		post_p	0.78 (0.75, 0.84)	0.56 (0.53, 0.85)			0.78 (0.62, 0.9)	0.58 (0.55, 0.7)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.043 (0.009, 0.051)	0.041 (0.008, 0.042)			0.044 (0.037, 0.05)	0.043 (0.009, 0.058)
TP53+	Hormone_therapies	count			3	3			3	3			3	3			3	3
		time			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n			18 (13, 23)	5 (5, 8)			2 (0, 3)	2 (1, 3)			5 (4, 7)	5 (1, 5)			2 (0, 4)	0 (0, 0)
		post_p			0.88 (0.81, 0.9)	0.72 (0.61, 0.81)			0.61 (0.57, 0.65)	0.63 (0.63, 0.67)			0.75 (0.57, 0.81)	0.54 (0.54, 0.54)			0.62 (0.56, 0.67)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.056 (0.052, 0.078)	0.084 (0.064, 0.085)			0.067 (0.013, 0.121)	0 (0, 0.06)			0.1 (0.046, 0.139)	0.065 (0.013, 0.116)			0.027 (0.005, 0.049)	NA (NA, NA)
	Taxel_therapies	count			9	9			9	9			9	9			9	9
		time			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)
		n			9 (6, 13)	11 (7, 15)			0 (0, 2)	1 (0, 3)			3 (2, 5)	3 (2, 5)			1 (0, 3)	1 (0, 3)
		post_p			0.76 (0.69, 0.86)	0.81 (0.67, 0.88)			0.65 (0.56, 0.75)	0.57 (0.52, 0.63)			0.57 (0.53, 0.85)	0.55 (0.51, 0.7)			0.59 (0.51, 0.72)	0.62 (0.53, 0.63)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.078 (0.054, 0.116)	0.05 (0.03, 0.093)			0 (0, 0)	0 (0, 0.039)			0.081 (0, 0.142)	0.062 (0, 0.092)			0 (0, 0.078)	0 (0, 0.034)
	Carboplatin	count			3	3			3	3			3	3			3	3
		time			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)
		n			14 (13, 15)	5 (2, 9)			2 (0, 3)	3 (2, 4)			2 (2, 4)	1 (1, 3)			2 (0, 4)	4 (3, 4)
		post_p			0.81 (0.77, 0.89)	0.53 (0.53, 0.8)			0.63 (0.6, 0.65)	0.66 (0.57, 0.7)			0.58 (0.58, 0.62)	0.64 (0.53, 0.64)			0.59 (0.56, 0.63)	0.69 (0.63, 0.73)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.043 (0.04, 0.052)	0.091 (0.018, 0.095)			0.222 (0.112, 0.332)	0 (0, 0.09)			0.091 (0.018, 0.132)	0 (0, 0.06)			0.088 (0.068, 0.108)	0.104 (0.07, 0.153)
	Niraparib	count			4	4			4	4			4	4			4	4
		time			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)
		n			16 (11, 22)	4 (1, 7)			3 (2, 5)	4 (1, 10)			2 (0, 3)	4 (2, 5)			3 (2, 4)	3 (1, 4)
		post_p			0.9 (0.8, 0.94)	0.72 (0.58, 0.77)			0.72 (0.55, 0.79)	0.75 (0.56, 0.92)			0.67 (0.64, 0.7)	0.75 (0.61, 0.79)			0.7 (0.59, 0.82)	0.7 (0.56, 0.86)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.053 (0.035, 0.067)	0.086 (0.063, 0.111)			0.107 (0.076, 0.135)	0.081 (0.018, 0.109)			0.046 (0.009, 0.082)	0.065 (0.014, 0.089)			0.092 (0.022, 0.113)	0.088 (0.018, 0.122)
DRD+	Hormone_therapies	count					7	7	7	7					7	7	7	7
		time					26 (20, 30)	26 (20, 30)	26 (20, 30)	26 (20, 30)					26 (20, 30)	26 (20, 30)	26 (20, 30)	26 (20, 30)
		n					1 (0, 4)	1 (1, 8)	4 (3, 8)	3 (3, 7)					2 (2, 3)	3 (1, 4)	4 (1, 5)	4 (3, 9)
		post_p					0.74 (0.64, 0.76)	0.84 (0.64, 0.91)	0.72 (0.62, 0.87)	0.73 (0.64, 0.84)					0.6 (0.52, 0.74)	0.65 (0.52, 0.76)	0.71 (0.6, 0.84)	0.71 (0.52, 0.82)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.03 (0.007, 0.052)	0 (0, 0.057)	0.063 (0.036, 0.116)	0.057 (0.019, 0.097)					0.055 (0, 0.083)	0.09 (0.016, 0.164)	0.065 (0.047, 0.087)	0.065 (0.028, 0.108)
	Carboplatin	count					1	1	1	1					1	1	1	1
		time					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
		n					9 (9, 9)	4 (4, 4)	2 (2, 2)	1 (1, 1)					5 (5, 5)	3 (3, 3)	0 (0, 0)	1 (1, 1)
		post_p					0.82 (0.82, 0.82)	0.71 (0.71, 0.71)	0.58 (0.58, 0.58)	0.51 (0.51, 0.51)					0.88 (0.88, 0.88)	0.7 (0.7, 0.7)	NA (NA, NA)	0.55 (0.55, 0.55)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.08 (0.08, 0.08)	0.049 (0.049, 0.049)	0 (0, 0)	0 (0, 0)					0.085 (0.085, 0.085)	0.057 (0.057, 0.057)	NA (NA, NA)	0 (0, 0)
	Niraparib	count					2	2	2	2					2	2	2	2
		time					12 (9, 14)	12 (9, 14)	12 (9, 14)	12 (9, 14)					12 (9, 14)	12 (9, 14)	12 (9, 14)	12 (9, 14)
		n					4 (3, 4)	7 (5, 9)	5 (4, 6)	2 (2, 3)					5 (5, 5)	0 (0, 1)	4 (4, 4)	4 (3, 4)
		post_p					0.6 (0.6, 0.62)	0.72 (0.7, 0.74)	0.84 (0.76, 0.92)	0.55 (0.51, 0.59)					0.68 (0.63, 0.73)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.59 (0.52, 0.66)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.042 (0.008, 0.076)	0.077 (0.07, 0.083)	0.012 (0.002, 0.021)	0.082 (0.016, 0.147)					0.04 (0.008, 0.072)	0.112 (0.112, 0.112)	0.098 (0.075, 0.121)	0.157 (0.07, 0.244)
TEfus+	Hormone_therapies	count		10		10		10		10		10		10		10		10
		time		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)
		n		5 (3, 6)		6 (5, 14)		2 (1, 4)		2 (1, 4)		2 (1, 7)		5 (2, 8)		2 (0, 4)		1 (0, 4)
		post_p		0.82 (0.72, 0.9)		0.74 (0.57, 0.88)		0.73 (0.6, 0.9)		0.64 (0.5, 0.87)		0.65 (0.55, 0.78)		0.64 (0.53, 0.76)		0.57 (0.52, 0.72)		0.61 (0.56, 0.75)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.023 (0, 0.057)		0.073 (0.051, 0.109)		0 (0, 0.045)		0 (0, 0.075)		0.082 (0, 0.107)		0.076 (0, 0.114)		0.072 (0, 0.11)		0 (0, 0.074)
	Taxel_therapies	count		3		3		3		3		3		3		3		3
		time		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)
		n		2 (0, 3)		15 (12, 17)		1 (0, 4)		1 (0, 2)		3 (2, 5)		4 (2, 10)		0 (0, 0)		0 (0, 2)
		post_p		0.54 (0.51, 0.56)		0.71 (0.7, 0.83)		0.63 (0.56, 0.7)		0.59 (0.52, 0.66)		0.71 (0.63, 0.71)		0.88 (0.75, 0.93)		NA (NA, NA)		0.6 (0.6, 0.6)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.045 (0.009, 0.08)		0.063 (0.062, 0.072)		0 (0, 0)		0.032 (0.006, 0.058)		0.055 (0.011, 0.08)		0.068 (0.014, 0.076)		NA (NA, NA)		0 (0, 0)
	Carboplatin	count		2		2		2		2		2		2		2		2
		time		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)
		n		2 (1, 2)		4 (2, 5)		3 (3, 3)		4 (3, 5)		4 (3, 6)		2 (1, 4)		6 (3, 8)		4 (3, 4)
		post_p		0.58 (0.52, 0.64)		0.58 (0.56, 0.59)		0.6 (0.53, 0.66)		0.72 (0.67, 0.77)		0.76 (0.74, 0.79)		0.69 (0.66, 0.72)		0.81 (0.81, 0.81)		0.65 (0.65, 0.66)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.114 (0.113, 0.115)		0.085 (0.069, 0.102)		0.018 (0.004, 0.032)		0.026 (0.005, 0.048)		0.022 (0.004, 0.039)		0.13 (0.127, 0.134)		0.048 (0.041, 0.054)
	Niraparib	count		3		3		3		3		3		3		3		3
		time		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)
		n		1 (0, 3)		8 (6, 9)		4 (4, 7)		3 (1, 5)		2 (1, 3)		2 (1, 4)		3 (2, 5)		4 (4, 4)
		post_p		0.52 (0.52, 0.53)		0.73 (0.59, 0.86)		0.62 (0.56, 0.79)		0.56 (0.51, 0.62)		0.64 (0.54, 0.66)		0.62 (0.58, 0.65)		0.67 (0.55, 0.67)		0.74 (0.71, 0.77)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.054 (0.034, 0.072)		0.048 (0.047, 0.056)		0.06 (0.012, 0.125)		0 (0, 0)		0 (0, 0.037)		0.101 (0.073, 0.285)		0.08 (0.016, 0.131)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)
		n	13 (13, 13)	2 (2, 2)	6 (6, 6)	3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.2 (0.2, 0.2)	0.34 (0.34, 0.34)	0.36 (0.36, 0.36)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.102 (0.102, 0.102)	0.292 (0.292, 0.292)	0.078 (0.078, 0.078)	0.206 (0.206, 0.206)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
		n	6 (5, 8)	3 (3, 4)	3 (2, 10)	6 (5, 8)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	3 (3, 4)	1 (0, 1)	1 (0, 4)	4 (1, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.44 (0.28, 0.46)	0.45 (0.45, 0.49)	0.48 (0.16, 0.48)	0.37 (0.33, 0.47)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.46 (0.46, 0.48)	0.39 (0.31, 0.47)	0.43 (0.43, 0.43)	0.35 (0.28, 0.41)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.114 (0.083, 0.306)	0.185 (0.037, 0.192)	0.141 (0.028, 0.234)	0.128 (0.127, 0.131)	1.07 (1.07, 1.07)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.124 (0.025, 0.211)	0.143 (0.029, 0.258)	0.712 (0.187, 1.236)	0.251 (0.216, 0.285)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)
		n	6 (4, 8)	0 (0, 0)	6 (4, 8)	4 (3, 6)	5 (5, 5)	6 (5, 6)	1 (0, 2)	1 (0, 2)	2 (1, 3)	2 (1, 2)	2 (1, 3)	0 (0, 0)	2 (1, 2)	2 (0, 3)	2 (1, 4)	4 (1, 6)
		post_p	0.29 (0.2, 0.38)	NA (NA, NA)	0.34 (0.27, 0.41)	0.4 (0.37, 0.42)	0.22 (0.12, 0.33)	0.45 (0.41, 0.48)	0.46 (0.46, 0.46)	0.49 (0.49, 0.49)	0.45 (0.43, 0.48)	0.39 (0.31, 0.47)	0.35 (0.24, 0.46)	NA (NA, NA)	0.34 (0.31, 0.37)	0.12 (0.12, 0.12)	0.33 (0.27, 0.39)	0.46 (0.46, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.161 (0.153, 0.169)	NA (NA, NA)	0.227 (0.154, 0.299)	0.203 (0.154, 0.253)	0.189 (0.09, 0.288)	0.112 (0.09, 0.135)	0.08 (0.08, 0.08)	0.095 (0.095, 0.095)	0.089 (0.018, 0.161)	0.171 (0.034, 0.307)	0.25 (0.218, 0.282)	NA (NA, NA)	0.209 (0.206, 0.212)	0.551 (0.551, 0.551)	0.245 (0.131, 0.359)	0.041 (0.041, 0.041)
	Niraparib	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)
		n	22 (13, 70)	5 (2, 15)	10 (8, 33)	4 (2, 17)	10 (4, 18)	2 (1, 8)	3 (3, 7)	1 (1, 2)	2 (1, 4)	4 (1, 6)	3 (2, 7)	4 (2, 5)	2 (2, 4)	3 (3, 5)	2 (2, 4)	2 (2, 6)
		post_p	0.06 (0.05, 0.37)	0.39 (0.38, 0.39)	0.14 (0.11, 0.43)	0.44 (0.21, 0.47)	0.33 (0.17, 0.4)	0.32 (0.32, 0.34)	0.24 (0.19, 0.34)	0.37 (0.32, 0.38)	0.41 (0.28, 0.42)	0.36 (0.35, 0.37)	0.3 (0.27, 0.45)	0.35 (0.27, 0.46)	0.19 (0.18, 0.2)	0.28 (0.24, 0.3)	0.18 (0.14, 0.43)	0.34 (0.24, 0.42)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.106 (0.103, 0.185)	0.153 (0.113, 2.178)	0.23 (0.138, 0.234)	0.122 (0.106, 1.745)	0.142 (0.105, 0.184)	0.2 (0.111, 4.306)	0.296 (0.172, 0.441)	0.326 (0.234, 0.335)	0.287 (0.183, 0.304)	0.144 (0.14, 0.148)	0.148 (0.122, 0.389)	0.178 (0.155, 0.39)	0.418 (0.226, 0.877)	0.197 (0.121, 0.394)	0.218 (0.139, 0.299)	0.267 (0.181, 0.485)
TP53- & AR-	Hormone_therapies	count	2	2			2	2
		time	6 (6, 7)	6 (6, 7)			6 (6, 7)	6 (6, 7)
		n	24 (22, 25)	2 (2, 3)			0 (0, 1)	1 (0, 2)
		post_p	0.4 (0.36, 0.45)	0.12 (0.05, 0.19)			0.49 (0.49, 0.49)	0.19 (0.19, 0.19)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.071 (0.056, 0.085)	0.766 (0.7, 0.832)			0 (0, 0)	0.177 (0.177, 0.177)
	Taxel_therapies	count	396	396			396	396
		time	21 (13, 33)	21 (13, 33)			21 (13, 33)	21 (13, 33)
		n	19 (8, 59)	6 (3, 16)			6 (2, 15)	5 (2, 14)
		post_p	0.16 (0.02, 0.41)	0.28 (0.1, 0.46)			0.35 (0.15, 0.48)	0.35 (0.17, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.117 (0.086, 0.197)	0.137 (0.086, 0.317)			0.132 (0.079, 0.428)	0.127 (0.08, 0.39)
	Carboplatin	count	391	391			391	391
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	18 (8, 56)	5 (1, 14)			7 (3, 15)	7 (3, 15)
		post_p	0.18 (0.03, 0.45)	0.34 (0.16, 0.48)			0.33 (0.13, 0.47)	0.35 (0.13, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.084, 0.182)	0.132 (0.081, 0.383)			0.126 (0.083, 0.309)	0.126 (0.081, 0.274)
	Niraparib	count	382	382			382	382
		time	21 (13, 32)	21 (13, 32)			21 (13, 32)	21 (13, 32)
		n	18 (8, 59)	5 (2, 15)			7 (2, 15)	7 (3, 16)
		post_p	0.18 (0.03, 0.45)	0.33 (0.13, 0.47)			0.33 (0.1, 0.48)	0.33 (0.13, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.083, 0.19)	0.138 (0.082, 0.428)			0.132 (0.088, 0.34)	0.129 (0.081, 0.34)
TP53+	Hormone_therapies	count			29	29			29	29			29	29			29	29
		time			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)
		n			14 (6, 29)	8 (3, 15)			2 (0, 3)	2 (1, 5)			3 (1, 7)	3 (1, 7)			2 (0, 4)	2 (1, 4)
		post_p			0.28 (0.09, 0.42)	0.36 (0.12, 0.48)			0.33 (0.18, 0.49)	0.42 (0.28, 0.47)			0.31 (0.22, 0.44)	0.32 (0.18, 0.49)			0.35 (0.15, 0.47)	0.34 (0.21, 0.47)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.146 (0.112, 0.236)	0.157 (0.091, 0.344)			0.239 (0.117, 0.493)	0.17 (0.044, 1.247)			0.227 (0.142, 1.247)	0.196 (0.104, 0.456)			0.416 (0.075, 0.955)	0.228 (0.094, 1.164)
	Taxel_therapies	count			29	29			29	29			29	29			29	29
		time			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)
		n			11 (5, 27)	10 (5, 16)			2 (0, 5)	2 (0, 4)			4 (1, 11)	4 (2, 8)			2 (0, 5)	2 (1, 5)
		post_p			0.34 (0.17, 0.46)	0.25 (0.13, 0.43)			0.31 (0.19, 0.43)	0.4 (0.28, 0.49)			0.38 (0.19, 0.46)	0.35 (0.14, 0.48)			0.33 (0.21, 0.45)	0.36 (0.22, 0.49)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.143 (0.103, 0.246)	0.15 (0.108, 0.197)			0.292 (0.148, 0.545)	0.18 (0.108, 0.793)			0.174 (0.124, 0.523)	0.137 (0.07, 0.462)			0.205 (0.02, 0.733)	0.196 (0.107, 0.78)
	Carboplatin	count			35	35			35	35			35	35			35	35
		time			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)
		n			11 (6, 20)	6 (2, 13)			3 (1, 7)	4 (2, 8)			3 (2, 11)	3 (1, 8)			2 (1, 8)	3 (1, 6)
		post_p			0.28 (0.09, 0.47)	0.33 (0.16, 0.47)			0.34 (0.19, 0.48)	0.41 (0.26, 0.49)			0.35 (0.19, 0.49)	0.35 (0.13, 0.47)			0.38 (0.19, 0.49)	0.34 (0.14, 0.46)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.146 (0.11, 0.227)	0.143 (0.104, 0.516)			0.207 (0.122, 1.072)	0.155 (0.097, 0.268)			0.151 (0.095, 0.33)	0.198 (0.1, 0.814)			0.168 (0.094, 1.099)	0.247 (0.095, 0.766)
	Niraparib	count			30	30			30	30			30	30			30	30
		time			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)
		n			10 (5, 40)	6 (4, 19)			3 (1, 8)	2 (1, 9)			3 (0, 7)	3 (1, 5)			3 (2, 6)	3 (1, 7)
		post_p			0.24 (0.12, 0.49)	0.38 (0.16, 0.46)			0.35 (0.18, 0.47)	0.33 (0.22, 0.48)			0.35 (0.23, 0.46)	0.38 (0.24, 0.48)			0.4 (0.22, 0.49)	0.35 (0.15, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.159 (0.114, 0.416)	0.131 (0.1, 0.333)			0.166 (0.108, 1.105)	0.234 (0.116, 0.635)			0.168 (0.13, 0.55)	0.184 (0.12, 0.664)			0.181 (0.109, 0.324)	0.165 (0.093, 0.544)
DRD+	Hormone_therapies	count					2	2	2	2					2	2	2	2
		time					26 (24, 27)	26 (24, 27)	26 (24, 27)	26 (24, 27)					26 (24, 27)	26 (24, 27)	26 (24, 27)	26 (24, 27)
		n					0 (0, 1)	2 (2, 2)	4 (3, 4)	7 (6, 8)					3 (2, 4)	1 (1, 1)	2 (1, 4)	6 (5, 8)
		post_p					0.42 (0.42, 0.42)	0.43 (0.41, 0.44)	0.24 (0.2, 0.28)	0.28 (0.22, 0.35)					0.27 (0.27, 0.28)	0.43 (0.38, 0.48)	0.27 (0.22, 0.32)	0.42 (0.35, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.123 (0.123, 0.123)	0.11 (0.108, 0.112)	0.241 (0.21, 0.272)	0.116 (0.105, 0.128)					0.362 (0.305, 0.419)	0.423 (0.246, 0.6)	5.716 (1.253, 10.18)	0.124 (0.079, 0.17)
	Taxel_therapies	count					40	40	40	40					40	40	40	40
		time					26 (20, 34)	26 (20, 34)	26 (20, 34)	26 (20, 34)					26 (20, 34)	26 (20, 34)	26 (20, 34)	26 (20, 34)
		n					6 (2, 17)	5 (2, 10)	2 (1, 5)	2 (0, 5)					4 (1, 8)	3 (1, 6)	2 (1, 8)	2 (1, 5)
		post_p					0.32 (0.19, 0.45)	0.31 (0.17, 0.45)	0.35 (0.18, 0.46)	0.34 (0.21, 0.48)					0.36 (0.19, 0.47)	0.38 (0.28, 0.48)	0.36 (0.25, 0.48)	0.38 (0.26, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.124 (0.088, 0.226)	0.129 (0.087, 0.253)	0.204 (0.108, 0.612)	0.243 (0.125, 1.44)					0.187 (0.133, 0.446)	0.164 (0.106, 0.534)	0.168 (0.109, 0.709)	0.217 (0.117, 0.516)
	Carboplatin	count					41	41	41	41					41	41	41	41
		time					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)
		n					7 (2, 14)	7 (3, 14)	3 (2, 7)	3 (1, 6)					4 (1, 8)	3 (1, 8)	5 (2, 8)	4 (1, 7)
		post_p					0.38 (0.14, 0.46)	0.3 (0.12, 0.43)	0.33 (0.18, 0.46)	0.37 (0.22, 0.45)					0.35 (0.23, 0.47)	0.38 (0.19, 0.47)	0.38 (0.13, 0.48)	0.36 (0.15, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.129 (0.087, 0.328)	0.13 (0.089, 0.243)	0.2 (0.104, 1.192)	0.203 (0.104, 0.4)					0.161 (0.107, 0.608)	0.149 (0.102, 0.597)	0.154 (0.101, 0.278)	0.195 (0.091, 0.593)
	Niraparib	count					42	42	42	42					42	42	42	42
		time					26 (14, 34)	26 (14, 34)	26 (14, 34)	26 (14, 34)					26 (14, 34)	26 (14, 34)	26 (14, 34)	26 (14, 34)
		n					5 (2, 14)	6 (3, 18)	4 (1, 9)	3 (1, 7)					4 (1, 6)	4 (1, 8)	4 (2, 6)	4 (2, 8)
		post_p					0.29 (0.13, 0.42)	0.29 (0.13, 0.47)	0.38 (0.19, 0.46)	0.32 (0.18, 0.48)					0.33 (0.21, 0.44)	0.34 (0.2, 0.46)	0.36 (0.18, 0.48)	0.38 (0.2, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.128 (0.088, 0.491)	0.134 (0.088, 0.374)	0.2 (0.117, 0.683)	0.247 (0.108, 1.097)					0.174 (0.115, 0.344)	0.187 (0.102, 0.662)	0.183 (0.091, 0.489)	0.161 (0.107, 0.372)
TEfus+	Hormone_therapies	count		3		3		3		3		3		3		3		3
		time		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)
		n		4 (2, 4)		9 (5, 18)		1 (0, 2)		2 (1, 2)		4 (3, 8)		3 (2, 5)		4 (3, 4)		2 (1, 4)
		post_p		0.36 (0.35, 0.4)		0.22 (0.18, 0.39)		0.44 (0.39, 0.49)		0.34 (0.25, 0.42)		0.38 (0.18, 0.46)		0.46 (0.25, 0.47)		0.42 (0.28, 0.43)		0.36 (0.31, 0.44)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.124 (0.091, 0.141)		0.153 (0.107, 0.333)		0.12 (0.103, 0.137)		0.827 (0.387, 0.924)		0.169 (0.143, 0.272)		0.211 (0.156, 0.542)		0.151 (0.11, 0.227)		0.166 (0.11, 3.035)
	Taxel_therapies	count		48		48		48		48		48		48		48		48
		time		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)
		n		4 (2, 12)		10 (5, 21)		4 (1, 9)		2 (0, 5)		5 (3, 10)		5 (2, 10)		2 (0, 7)		2 (0, 4)
		post_p		0.31 (0.13, 0.45)		0.32 (0.1, 0.47)		0.33 (0.12, 0.45)		0.35 (0.25, 0.48)		0.39 (0.23, 0.48)		0.34 (0.16, 0.47)		0.35 (0.24, 0.47)		0.35 (0.2, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.161 (0.077, 0.337)		0.146 (0.111, 0.238)		0.164 (0.106, 0.568)		0.188 (0.111, 1.131)		0.137 (0.104, 0.346)		0.15 (0.101, 0.458)		0.19 (0.105, 0.643)		0.195 (0.079, 0.768)
	Carboplatin	count		42		42		42		42		42		42		42		42
		time		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)
		n		4 (1, 9)		6 (4, 16)		6 (2, 11)		4 (1, 6)		3 (1, 7)		3 (1, 8)		3 (1, 7)		3 (1, 7)
		post_p		0.3 (0.18, 0.45)		0.34 (0.16, 0.47)		0.35 (0.14, 0.47)		0.35 (0.19, 0.47)		0.37 (0.24, 0.46)		0.35 (0.2, 0.45)		0.36 (0.23, 0.48)		0.37 (0.17, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.151 (0.076, 0.416)		0.157 (0.107, 0.311)		0.126 (0.086, 0.255)		0.155 (0.115, 0.539)		0.168 (0.096, 0.699)		0.185 (0.119, 0.786)		0.181 (0.108, 0.615)		0.173 (0.105, 0.318)
	Niraparib	count		30		30		30		30		30		30		30		30
		time		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)
		n		4 (1, 14)		8 (4, 22)		5 (3, 10)		3 (1, 7)		3 (1, 6)		4 (2, 8)		4 (1, 8)		4 (1, 8)
		post_p		0.37 (0.13, 0.45)		0.38 (0.15, 0.48)		0.25 (0.13, 0.46)		0.38 (0.18, 0.48)		0.37 (0.22, 0.47)		0.4 (0.19, 0.49)		0.33 (0.16, 0.49)		0.34 (0.22, 0.49)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.146 (0.085, 0.747)		0.14 (0.102, 0.285)		0.155 (0.095, 0.413)		0.176 (0.11, 0.449)		0.206 (0.118, 0.654)		0.171 (0.095, 0.338)		0.136 (0.091, 1.132)		0.164 (0.096, 0.579)